Publications by authors named "Kumar D Shanmukha"
Article Synopsis
- HDAC3 and NCoR1/2 are crucial epigenetic regulators that influence gene expression and metabolism by acting as transcriptional co-repressors.
- Genetic deletion of HDAC3 and NCoR1 in mice has shown improved glucose tolerance and insulin sensitivity, indicating their significant roles in managing metabolic processes.
- Disruption of the HDAC3/NCoR1/2 complex is linked to cardio-metabolic diseases like obesity and type 2 diabetes, highlighting the potential for targeting this pathway in future therapies.
Histone Deacetylases (HDACs) deacetylate lysine residues in histone and non-histone proteins. HDACs have been implicated in several diseases, including cancer, neurodegeneration, and cardiovascular disease. HDACs play an essential role in gene transcription, cell survival, growth, and proliferation, with histone hypoacetylation as one of the critical downstream signatures.
View Article and Find Full Text PDFTill date, several groups have studied the mechanism of microRNA (miRNA) biogenesis, processing, stability, silencing, and their dysregulation in cancer. The miRNA coding genes recurrently go through abnormal amplification, deletion, transcription, and epigenetic regulation in cancer. Some miRNAs function as tumor promoters while few others are tumor suppressors based on the transcriptional regulation of target genes.
View Article and Find Full Text PDFCatecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic and cardioprotective function of ABHD5. ABHD5 acts and as a serine protease cleaving HDAC4.
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