Publications by authors named "Kristyn Kavazos"
Article Synopsis
- This study investigated the effects of a low versus high omega-3 polyunsaturated fatty acid (n-3 PUFA) diet on mice lacking apolipoprotein E (ApoE(-/-)) in the context of pre-abdominal aortic aneurysm induced by angiotensin II infusion.
- Mice on a high n-3 PUFA diet showed lower levels of matrix metalloproteinase-9 (MMP-9) in endothelial and inflammatory cells compared to those on a low diet, along with increased levels of TIMP-1 and TGF-β1.
- The findings suggest that a high n-3 PUFA diet may reduce elastin degradation and inflammation, indicating potential protective effects against vascular issues.
Abdominal aortic aneurysm is associated with infiltration of inflammatory cells into the aortic wall. The inflammatory response is also evident in animal models, such as apolipoprotein E-deficient (ApoE-/-) mice that have been infused with angiotensin II, prior to development of aortic aneurysm. Since omega-3 polyunsaturated fatty acids (n-3 PUFAs) and their metabolites have anti-inflammatory and pro-resolving activity, we hypothesised that dietary supplementation with n-3 PUFAs would protect against inflammatory processes in this mouse model.
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