Climate and health-relevant pollutant emissions from oil and natural gas boilers.

Emission factor data for existing heating appliances are being used to estimate achievable emission reductions with emerging heating technologies. However, the emission factors currently being used for modeling were developed prior to low-sulfur fuel standards and rely on a small number of studies, mostly focusing on steady-state operation. In this work, detailed emission measurements of typical heating equipment fired with natural gas and No.

Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70-year-olds.

Background Aging involves heterogeneous brain grey matter (GM) loss patterns that may overlap with dementia-related changes. We evaluated cognitively unimpaired older adults to identify specific GM patterns, their clinical and cognitive profiles, and longitudinal trajectories. Methods We analyzed 746 participants from the Gothenburg H70 Study using random forest clustering based on MRI measures of cortical thickness and subcortical volume across 41 regions.

Study protocol: ACCESS: (Advancing Contraceptive Equity and Service Uptake through Telemedicine in the US Safety-Net).

Access to desired contraceptive care is a critical component of reproductive autonomy. Telemedicine (TM), or the remote provision of clinical services via technology, in community-based health centers has the potential to expand access to family planning services, potentially enhancing both reproductive autonomy and equity. However, little is known about which patient populations use TM for contraceptive services in the US " safety net" (community-based health centers), if there are inequities in access to TM care, or patient preferences for TM contraceptive care.

Sternal opening width is associated with increased risk for capillary leak syndrome and death in neonates and infants after cardiac surgery with delayed sternal closure.

Capillary leak syndrome is a serious postoperative complication in neonates and infants after open-heart surgery for CHD. The aim of this study was to investigate the relationship between sternal opening width and the occurrence of capillary leak syndrome in patients undergoing cardiac surgery with delayed sternal closure.We retrospectively analysed the clinical data of neonates and infants (aged < 12 months) who underwent open-heart surgery with delayed sternal closure at our institution between January 2016 and December 2021.

Image quality assessment of photon-counting CT for patients with prostate cancer receiving radiotherapy.

Background And Purpose: Photon-counting computed tomography (PCCT) offers enhanced image quality, including improvements in contrast, spatial resolution, and noise reduction. In radiotherapy (RT), optimal image quality is critical for accurate tumor and organ-at-risk delineation. However, reconstruction parameter selection often relies on subjective assessment.

Sentinel Injuries in Emergency Departments and Subsequent Serious Injury in Children.

Study Objective: Sentinel injuries in young children are minor injuries that can raise suspicion of physical abuse. Although early identification is critical, widespread screening of patients can incur unintended harm to both children and their families. We determined the frequency of serious abusive injury within 12 months following an emergency department (ED) encounter for a sentinel injury.

Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury.

The adult mammalian heart has a limited ability to regenerate lost myocardium following myocardial infarction (MI), largely due to the poor proliferative capacity of cardiomyocytes. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a known regulator of cell quiescence, though the mechanisms underlying its function remain unclear. Previous studies have shown that pharmacological inhibition of DYRK1A using harmine induces cardiomyocyte cell cycle re-entry after ischemia/reperfusion (I/R) MI.

Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome.

Brain age, as distinct from chronological age, may reveal post-stroke recovery mechanisms, but longitudinal studies tracking brain age are lacking. We explored longitudinal change of brain age post-stroke and its relation to upper limb sensorimotor outcome. T-weighted MRI at baseline (∼3 weeks) and follow-up (3-7 months) post-stroke was used to estimate brain age.

Impact of the clinical nurse specialist role for the myeloproliferative neoplasm program: Part Two - The team and patient care experiences.

Myeloproliferative neoplasms (MPN) are a group of rare clonal disorders of hematopoietic progenitor cells associated with disease- related symptoms, thrombotic events, and risk of transformation to acute myeloid leukemia (Tefferi, 2021). Their relative rarity and complexity of care led to the establishment of the MPN program at the Princess Margaret (PM) Cancer Centre, Toronto, Canada. The MPN program utilizes a shared-care model wherein partnering with local hematologists (shared-care partners) ensures that patients have access to a MPN specialist while continuing to receive care close to home.

Seasonal variations in ventricular repolarization and tachyarrhythmias in hibernating brown bears (Ursus arctos arctos).

In humans, hypothermia prolongs ventricular repolarization and associates with sustained ventricular tachyarrhythmias. In bears, body temperature drops during hibernation similar to moderate human hypothermia, yet they rarely face fatal outcomes during the winter. This suggests protective adaptations in bear electrophysiology.

DYRK1A inhibition restores pancreatic functions and improves glucose metabolism in a preclinical model of type 2 diabetes.

Objectives: Insulin deficiency caused by the loss of β cells and/or impaired insulin secretion is a key factor in the pathogenesis of type 2 diabetes (T2D). The restoration of β cell number and function is thus a promising strategy to combat diabetes. Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) has been shown to regulate human β cell proliferation.

Impact of the clinical nurse specialist role for the myeloproliferative neoplasm program: Part One - From timeliness of triage to cost-saving.

Myeloproliferative neoplasms (MPNs) are a group of rare clonal disorders of hematopoietic progenitor cells associated with disease-related symptoms, thrombotic events, and risk of transformation to acute myeloid leukemia (Tefferi, 2021). The relative rarity and complexity of care led to the establishment of the MPN program at the Princess Margaret (PM) Cancer Centre. The MPN program utilizes a shared-care model wherein partnering with local hematologists (shared-care partners) ensures that patients have access to an MPN specialist while continuing to receive care close to home (Cheung et al.

Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer.

Background: T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information.

Methods: We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patients with NSCLC.

The Suitability, Readability, and Accuracy of Food Security Resources for Refugees Resettling in Australia.

Objective: Refugees are highly susceptible to food insecurity during resettlement, a time when access to quality information is vital. This study's objective was to analyze a national sample of food security information resources' suitability, accuracy, and currency for refugee populations.

Methods: Resources were categorized and then analyzed using Suitability Assessment of Materials; Simple Measure of Gobbledygook; and currency, relevance, accuracy, authority, and purpose.

Thoughts on and Motives for Leaving the First-Line Manager Position: A Qualitative Study.

The aim of this study was to describe first-line managers' thoughts on and motives for leaving their position. The turnover rate of first-line managers impacts healthcare organizations' overall performance. Burnout, dissatisfaction, and desired career advancement contribute to the intention to leave.

"Trust, Responsibility, and Making a Difference": Qualitative Insights into Why First-Line Managers in Healthcare Remain in Their Role.

Healthcare organizations face increasing challenges in retaining first-line managers, who play a key role in operational stability and patient care. Studies indicate that approximately half of all first-line managers intend to leave their position within 5 years. This highlights the need for updated knowledge about conditions under which they work.

Wellbeing Among Police Personnel Investigating Online Child Sexual Abuse: A Scoping Review.

Online child sexual abuse (CSA) crimes have increased significantly in recent years, reflecting broader access to the internet and the global proliferation of CSA content. In response, national police forces have established specialized investigative teams. Notably, repeated exposure to CSA material has been identified as a significant stressor for police personnel, potentially increasing the risk of secondary traumatic stress and burnout.

Impact of Primary Chronic Immune Thrombocytopenia and Thrombopoietin Receptor Agonists Treatment Instructions on Daily Living: Results of a Multinational Cross-Sectional Survey.

Purpose: Thrombopoietin receptor agonists (TPO-RAs) are second-line treatments for people with immune thrombocytopenia (ITP). A survey was conducted to evaluate the understanding of and adherence to TPO-RA treatment instructions, and to determine the impact of ITP and TPO-RAs on daily living.

Patients And Methods: Cross-sectional, self-administered, online survey conducted from September 2023 to April 2024.

Pre- and postoperative pain management practices in fracture surgery: A bicentric prospective observational study in Ethiopia.

Background: Acute pain is common following orthopedic trauma and surgery. This study aims to evaluate the adequacy of pre- and postoperative pain management in traumatic fracture patients undergoing orthopedic surgery in Ethiopia.

Methods: A prospective cohort study was conducted at two Ethiopian trauma centers from January 2019 to October 2021.

Nasogastric tube after oesophagectomy and risk of anastomotic leak: a Nordic, multicentre, open-label, randomised, controlled, non-inferiority trial.

Background: Oesophagectomy, a corner stone in curative treatment of oesophageal cancer, is a complex procedure with high complication rates. Postoperative gastric tube decompression is debated and some centres are abandoning routine nasogastric (NG) tube use. We hypothesised that postoperative NG tube removal is non-inferior to five days of NG tube decompression, with regard to the risk of anastomotic leak.

A comparative study and review of visual outcomes with enhanced versus standard monofocal intraocular lenses following cataract surgery.

Background: Recent innovations in intraocular lens (IOL) design have introduced extended depth of focus lenses, which has shown promise in improving visual acuity at multiple distances while preserving the distance vision provided by a standard monofocal IOL. This study aimed to evaluate the visual outcomes of TECNIS Eyhance, a monofocal IOL with enhanced intermediate function, and a standard TECNIS monofocal 1-piece IOL, and to review published studies comparing the clinical performance between the TECNIS Eyhance and standard IOLs.

Methods: A retrospective analysis was conducted on patients who underwent cataract extraction with bilateral implantation of either TECNIS Eyhance IOLs or TECNIS Monofocal 1-Piece IOLs.

Effects of additives on the rheology and phase behavior of lamellar-structured concentrated surfactant solutions.

Structure-property-processing relationships for model lamellar structured 70 wt% SLES solutions were developed with a combination of rheometry, cross-polarized optical microscopy, calorimetry, small angle X-ray scattering, and rheo-ultrasonic speckle velocimetry. Additives were utilized to maintain high surfactant activity, reduce bulk viscosity and simplify processing. While the bulk flow behavior of neat SLES solutions was similar, the effect of some additives was sensitive to the degree of ethoxylation.