Local responses in primary and secondary human lung cancers. II. Clinical correlations.

Local infiltrates of eosinophilic leucocytes and macrophages and the deposition of acid mucopolysaccharides (AMPS) in 72 operable primary lung cancers and 17 isolated pulmonary metastases of known origin were correlated to tumour stage (radically or non-radically operable) and clinical course, by following the patients for 2-3 1/2 years. Half of the primary lung cancers showed strong local eosinophilia which, in combination with either strong macrophage infiltration or absence of AMPS reaction, characterized a very good prognosis in radically operable patients. No eosinophils, together with a strong AMPS reaction, indicated a very poor prognosis, irrespective of tumour stage.

Local responses in primary and secondary human lung cancers. I. Patterns of cellular (eosinophils and macrophages) and extracellular (acid mucopolysaccharide) reactions.

Local free cell (eosinophils and macrophages) and extracellular (acid mucopolysaccharides) reactions were studied by histochemical techniques in 72 primary lung cancers (Group A), 17 pulmonary metastases and 5 lung tumours of unknown origin (Group B). Strong cellular reactions were more frequent in Group A than in Group B, whereas extracellular reactions were more frequent in Group B than in Group A. In both groups the degrees of eosinophilic infiltration and accumulation of acid mucopolysaccharides tended to be negatively correlated.

[Animal experimental studies on partial kidney function after temporary tourniquet ischemia with and without blood substitute therapy].

70 rats were subjected to tourniquet ischemia of a hind limb for a period of two and three hours. 12 rats served as controls. After release of the 3 hours tourniquets 20 rats were treated either with Ringer's solution or with hydroxyethyl starch.

[Early rejection of intraportal and intralinear pancreas allotransplants].

Allogeneic pancreatic microfragments were transplanted into the portal vein or splenic pulp of two groups of 10 dogs. The transplants were rejected after 2.4 and 3.

[Studies of the presence of enzymes in various tissues of swine. 4. Studies of the Ca-, Mg-, and Na-K-ATPase activities in the homogenate and cell fractions of brain of fetuses and piglets].

Studies were conducted into the activities of calcium, magnesium, and sodium-potassium ATPase as well as into crude protein levels in homogenate and cell fractions of brain of two foetuses, aged 111 days, and of two piglets each, aged two days or nine weeks. The average brain-borne crude protein percentages were 6.55 in the foetuses, 7.

[Studies of the regulation potential of glucose metabolism in the calf following infusion of fructose solution and using various hormones (ACTH, prednisolone, adrenaline and noradrenaline)].

Infusion of fructose solution (25 g in 100 ml) in sugar rations of 0.5 g or 1.0 g per kilogram of body weight usually induced in calf temporary drop of glucose in the blood plasma.

[Enzyme arrangement of various tissues in swine. 3. Studies of pre- and postnatal activities of various enzymes (ATPase, GOT, GPT, leucine aminopeptidase, acid and alkaline phosphatases, aldose reductase, glucuronate reductase, sorbitol dehydrogenase) in various tissues].

The crude protein levels as well as the activities of various enzymes were studied in certain tissues of fetuses (80th through 114th days of development), piglets of different age groups, and pigs for slaughter. In most of the tissues tested the postnatal activities of Na-K-ATPase were beyond those recorded from fetuses. The highest GOT activities were recorded from the liver, myocardium, and kidneys.

[Enzyme arrangement of various tissues in swine. 2. Studies of postpartum development of crude protein levels as well as activities of various enzymes (GOT, GPT, serine dehydratase, xanthine oxidase, fructose-1,6-diphosphatase) in liver, kidneys and muscle of piglets].

Twenty-eight piglets from three litters were analysed for postnatal development (0 to 6 days of age) of the crude protein levels and activities of various enzymes (GOT, GPT, serine dehydratase, xanthinoxidase, fructose-1,6-diphosphatase) in the supernatant of liver, kidneys, and muscles. Both the weight and crude protein levels of the liver increased after birth, which improved the capability of metabolic regulation. GOT and fructose 1,6-diphosphatase activities in the liver tissue increased over the first days after birth.

[Enzyme arrangement of various tissues in swine. 1. Studies of the effect of 32 hours of fasting, administration of actinomycin D, and fasting in combination with administration of actinomycin D on crude protein level, activities of GOT, GTP, fructose-1,6-diphoaphatase as well as ATPase of liver, kidneys and semitendinous muscle in newborn piglets].

The effects of sufficient milk intake as well as of 32 hours of fasting after birth, administration of actinomycin D (intraperitoneal application of 1 mg/kg five weight), and fasting in combination with actinomycin D on the development of body and liver weights, crude protein levels in homogenate and supernatant of liver, kidneys, and M. semitendinosus as well as on the activities of certain tissue enzymes were analysed with four groups of piglets (n = 4). Fasting, administration of actinomycin, and fasting in combination with actinomycin D resulted in rapid reduction in body and liver weights, while the crude protein levels in those tissues were not affected with significance.

[Studies of the presence of enzymes in various tissues of swine. 5. Studies of the activity and properties of adenosine triphosphatases in the pancreas].

Studies were conducted into the activities of magnesium-ATPase, sodium-potassium-ATPase, and HCO3-ATPase in homogenates of pancreas of 19 foetuses, with body weights between 340 g and 1,642 g, two piglets, with body weights of 9 kg and 10 kg, and four adult pigs. While general enzyme activity was low during foetal development, highest activies usually were recordable from HCO3-ATPase. High activities were recorded from both the piglets and adult pigs.

[The activity and properties of fructose-1,6-diphosphatase in various tissues (Liver, Kidneys, skeletal muscle, small intestine mucosa) in swine].

The following parameters are recommended for activity determination of FDPase by release of inorganic phosphate at 37 degrees C of enzyme from liver and kidneys of swine: pH 7.5, 2 mMol concentration of fructose-1,6-diphosphate, 5 mMol concentration of Mg ions, and ten minutes of incubation. When the activity of FDPase was analysed with temperatures of 22 degrees C, and 45 degrees C, rises were recorded up to the highest temperature.

[Ketamine--a suitable agent for emergency situations (author's transl)].

Various surgical procedures have been performed using ketamine alone (Group I) or ketamine-relaxant-air anaesthesia (Group II). In all patients we observed a significant rise in systolic and diastolic blood pressure and pulse rate. The intraoperative values showed a tendency to return to normal.

Malignant transformation of hyperplasiogenic polyps of the stomach--case report.

Case report of a 71 years old female with multiple hyperplasiogenic gastric polyps with malignant transformation of two polyps. So far, the hyperplasiogenic polyp was considered to be only an "indicator lesion" because the incidence of gastric cancer (apart from the polyps themselves) was found to be increased in these patients. This opinion has to be revised in view of the present case.

[The influence of Halothane on surfactant activity of the lung (author's transl)].

Halothane, momentarily the most popular inhalation anaesthetic, was examined in respect of its surfactant irritating properties in 13 rabbits. After five hours IPPB-anaesthesia with this compound there was a highly significant fall of the compliance quotient (CQ), at the moment the most reliable criterion for the surfactant activity "in situ", from 3.34 to 2.

[Influence of ventilatory pattern on the functional situation of the lung during inhalation anaesthesia. Part I: Spontaneous breathing versus IPPB (author's transl)].

After five hours breathing spontaneously enflurane, halothane and methoxyflurane only the rabbits under enflurane showed, apart from a mild respiratory acidosis, no deterioration of pulmonary functional situation. Halothane and methoxyflurane exhibited under the same conditions a significant worsening of elastic behaviour of the lung. The structural bases of the mechanical impairment were atelectasis, dystelectasis and interstitial edema.

[Acupuncture for pains of the face and the head is there any reasonable application? (author's transl)].

The physiological bases of the treatment with Acupuncture as well as its practical application in pain therapy were discussed at the meeting of the ORL-Society of Munich on the 4th December, 1976.

Intraportal and intrasplenic autotransplantation of pancreatic islets in the dog.

Autotransplantation of pancreatic microfragments into the liver or the spleen of totally pancreatectomized dogs is described. Both modes of transplantation resulted in restoration of normal fasting blood glucose levels. A delayed response to high glucose loads was however observed in both groups.

[Activation of vitamin D 3 and the mode of action of 1,25-hydroxycholecalciferol and 24,25-hydroxycholecalciferol].

A survey is given on the present state of the animal-biochemical research concerning the effectivity of the D-vitamins. The vitamin D3 is transferred in 25-hydroxycholecalciferol in the microsome fraction of the liver. Then in the kidneys a transformation into the physiologically active forms - the 1,25- and the 24,25-hydroxycholecalciferol - takes place.