Publications by authors named "Kobe Janssen"
Background: Next-generation sequencing technologies yield large numbers of genetic alterations, of which a subset are missense variants that alter an amino acid in the protein product. These variants can have a potentially destabilizing effect leading to an increased risk of misfolding and aggregation. Multiple software tools exist to predict the effect of single-nucleotide variants on proteins, however, a pipeline integrating these tools while starting from an NGS data output list of variants is lacking.
View Article and Find Full Text PDFExploiting the intrinsic misfolding propensity of the KRAS oncoprotein.
Proc Natl Acad Sci U S A
February 2023
Article Synopsis
- Mutant KRAS is a key factor in many cancers but is difficult to target with traditional drugs, prompting researchers to seek alternative methods.
- The study reveals that specific regions in KRAS are prone to aggregation, especially in common mutations, making them potential weak points that can be manipulated.
- By using synthetic peptides (Pept-ins™) from these regions, researchers were able to induce misfolding of mutant KRAS, leading to reduced cancer cell growth and tumor shrinkage in mice.