Publications by authors named "Klemen Mezgec"
Article Synopsis
- Modular protein engineering allows for the creation of high-molecular-weight assemblies and nanoscale biomaterials with precision, inspired by the structure of human dystrophin.
- The study focuses on designing elongated nanorods using a module of three tandem spectrin repeats that self-assemble through coiled-coil peptides, ensuring structural integrity and continuity of the α-helix.
- The resulting rigid rods, measured by advanced microscopy techniques, can be equipped with various proteins or peptides along their length, showcasing their potential as functionalized biomaterials in research and applications.
Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract.
J Control Release
July 2024
The delivery of vaccines plays a pivotal role in influencing the strength and longevity of the immune response and controlling reactogenicity. Mucosal immunization, as compared to parenteral vaccination, could offer greater protection against respiratory infections while being less invasive. While oral vaccination has been presumed less effective and believed to target mainly the gastrointestinal tract, trans-buccal delivery using mucoadhesive films (MAF) may allow targeted delivery to the mucosa.
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