Publications by authors named "Kira D Novakofski"
Article Synopsis
- A 21-year-old African American female sprinter experienced right foot pain, fatigue, and an unusual continuous menstrual cycle despite a contraceptive implant for three years.
- An MRI revealed a likely stress fracture in her foot and abnormal bone marrow signals, leading to further investigation after ongoing pain.
- The results showed severely high triglyceride levels and diabetes, indicating a rare congenital lipodystrophy that initially appeared as a stress fracture and unusual menstrual issues.
Background: Data on the long-term outcomes of nonoperative treatment of anterior shoulder instability are lacking, particularly for the US population. The purpose was to (1) describe the characteristics of patients with anterior shoulder instability treated nonoperatively, (2) assess the long-term outcomes of nonoperative management in a US population, and (3) identify risk factors for poor outcomes following nonoperative management.
Methods: A geographic cohort of >500,000 subjects was used to identify patients treated nonoperatively for anterior shoulder instability.
Article Synopsis
- * Current imaging methods fall short in detecting very small damages (submicrometer level) which can be crucial for timely treatment.
- * Newer techniques, such as optical coherence tomography and ultrasonography, can identify damage earlier but face limitations in joint coverage and depth of penetration.
Objective: Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype is desired for cartilage repair procedures.
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- Cellular pluripotency is linked to the expression of specific genes (NANOG, SOX2, POU5F1), with some claiming mesenchymal progenitor cells (MPCs) may express these genes at higher levels than other adult cells.
- This study aimed to compare gene expression and DNA methylation of these genes in equine MPCs, induced pluripotent stem (iPS) cells, fetal fibroblasts, fetal brain cells, and adult chondrocytes.
- Findings showed that iPS cells had significantly higher levels of NANOG, SOX2, and POU5F1 compared to adult cells, and there was an inverse relationship between gene expression and DNA methylation, challenging
Small GTPase proteins mediate changes in cellular morphology and other cellular functions. The aim of this study was to examine signaling of the small GTPase Cdc42 by stimulating chondrocytes grown in monolayer with long- (96 h) or short- (2 and 30 min) term exposure to interleukin-1α (IL-1α), IL-6, or IL-8. Quantitative PCR was used to determine changes in collagen type IIB (COL2A1), aggrecan (AGG), and matrix metalloproteinase-13 (MMP-13) gene expression after prolonged cytokine exposure.
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