Publications by authors named "Kim Denton"
Article Synopsis
- The study focused on improving loco-regional control in stage II and III head and neck squamous cell carcinoma using an intensified radiation therapy combined with cetuximab, aiming to minimize late normal tissue toxicity.
- In a phase I/II trial with 27 patients, the treatment was generally well-tolerated, with most experiencing acute toxicities like pain and oral mucositis, but only a few had significant late toxicities after 12 months.
- The results indicated promising survival rates and quality of life outcomes, suggesting that this therapy regimen is both effective and safe for the treatment of HNSCC.
Article Synopsis
- - The study investigates the use of sorafenib, a multikinase inhibitor, to treat advanced adenoid cystic carcinoma (ACC), which has poor chemotherapy response rates and limited success with targeted agents.
- - In a phase II trial, 23 patients were treated daily with sorafenib, resulting in median progression-free survival of 11.3 months and overall survival of 19.6 months, with 6-month and 12-month PFS rates of 69.3% and 46.2%.
- - Sorafenib was found to have modest effectiveness in ACC but was associated with significant side effects, leading to the conclusion that it is not recommended for further evaluation based on its limited benefits and high toxicity.
