Algal Metabolites as Novel Therapeutics Against Methicillin-Resistant (MRSA): A Review.

Methicillin-resistant (MRSA), a multidrug-resistant pathogen, poses a significant threat to global healthcare. This review evaluates the potential of marine algal metabolites as novel antibacterial agents against MRSA. We explore the clinical importance of , the emergence of MRSA as a "superbug", and its resistance mechanisms, including target modification, drug inactivation, efflux pumps, biofilm formation, and quorum sensing.

The effect of quaternary ammonium compounds (QACs) on quorum sensing and resistance of P. aeruginosa in clinical settings.

Pseudomonas aeruginosa, a formidable opportunistic pathogen, is notorious for its ability to form biofilms and produce virulence factors that favor chronic infections, especially in cystic fibrosis patients. The misuse of disinfectants, combined with environmental leakage and biodegradation, has led to widespread exposure of microorganisms to sub-lethal concentrations of disinfectants, particularly quaternary ammonium compounds (QACs). This study investigates the interaction between QACs, specifically ethylbenzalkyl dimethyl ammonium chloride (EBAC), and the quorum sensing (QS) mechanisms governing P.

Evaluating the Expression of Efflux Pumps in in Exposure to Sodium Dodecyl Sulfate, Didecyldimethylammonium Chloride, and Octenidine Dihydrochloride.

Emerging resistance of Gram-negative bacteria, including , to commonly used detergents and disinfectant is encountering us with hazard. Inappropriate use of disinfectants has forced bacteria to gain resistance. The ability of bacteria to extrude substrates from the cellular interior to the external environment has enabled them to persist in exposure to toxic compounds, which is due to existence of transport proteins.

Plant mediated biosynthesis of MnO nanostructures and their biomedical applications.

Nanomaterials have drawn significant attention for their biomedical and pharmaceutical applications. In the present study, manganese tetra oxide (MnO) nanoparticles were prepared greenly, and their physicochemical properties were studied. acetone extract was used as a safely novel precursor for reducing and stabilizing nanoparticles.

seed based green synthesis of copper nanoparticles: Characterization, environmental remediation and antimicrobial activity.

Textile dyes and heavy metals like hexavalent chromium [Cr(VI)] are considered major water pollutants. In addition, microbial contamination also seriously threatens potable water availability. The present study used seed aqueous extract to synthesize copper nanoparticles (MOS-CuNPs).

Plant extract-mediated synthesis Cobalt doping in zinc oxide nanoparticles and their cytotoxicity and antibacterial performance.

In this research, zinc oxide (ZnO) nanoparticles doped with different percentages of produced cobalt using the green synthesis method. ZnO nanoparticles showed good cellular and microbial toxicity due to their high surface-to-volume ratio. Adding cobalt metal to the nanostructure can lead to the appearance of a new feature.

Biosynthesis cobalt-doped nickel nanoparticles and their toxicity against disease.

The nanostructures have the great potential for novel medical and drug delivery applications. In present paper a green approach for the preparation of pure nickel oxide (NiO) and 5% cobalt-doped NiO (Co╫NiO) nanoparticles (NPs) by using Prosopis fracta extract have been study. The product of Co╫NiO NPs was proved through the PXRD, Raman, UV-Vis, FESEM, and EDX analyses.

Bio-Characterization and Liquid Chromatography-Mass Spectrometry Analysis of Exopolysaccharides in Biofilm-Producing Cyanobacteria Isolated from Soil Crust: Exploring the Potential of Microalgal Biomolecules.

Exopolysaccharide-producing cyanobacterial strains in biological soil crusts are described, in addition to their chemical properties and antioxidant and flocculation activities. The EPSs from Pudukkottai blackish biological soil crusts (PBBSCs) showed significant amounts of total soluble proteins (0.1687 mg/mL) and carbohydrates (0.

Optimization Study of the Capacity of as a Potential Bio-Remediator for the Bio-Adsorption of Arsenic (III) from Aquatic Environments.

This study examined the ability of the green microalgae to remove arsenic from aqueous solutions. A series of studies was conducted to determine the optimal conditions for biological arsenic elimination, including biomass amount, incubation time, initial arsenic level, and pH values. At 76 min, pH 6, 50 mgL metal concentration, and 1 gL bio-adsorbent dosage, the maximum removal of arsenic from an aqueous solution was 93%.

Optimized synthesis of silver nanoparticles using the marine fungus and its application against resistant nosocomial pathogens.

The prevalence of bacterial infections in hospitals is rising, endangering currently accessible, efficient medical treatments and increasing demand for novel medications. Metal nanoparticles (NPs) are showing promise as materials for the development of treatments and preventative measures. This study investigated the potential of the fungus Aspergillus terreus to produce silver nanoparticles (AgNPs) as a means of creating green technology to synthesize NPs.

Evaluation of citrus pectin capped copper sulfide nanoparticles against Candidiasis causing Candida biofilms.

The incidence of candidiasis has significantly increased globally in recent decades, and it is a significant source of morbidity and mortality, particularly in critically ill patients. Candida sp. ability to generate biofilms is one of its primary pathogenic traits.

In vitro anticancer and antibacterial performance of biosynthesized Ag and Ce co-doped ZnO NPs.

The great potential of zinc oxide nanoparticles (ZnO NPs) for biomedical applications is attributed to their physicochemical properties. In this work, pure and Ag and Ce dual-doped ZnO NPs were synthesized through a facile and green route to examine their cytotoxicity in breast cancer and normal cells. The initial preparation of dual-doped nanoparticles was completed by the usage of taranjabin.

Vermi-cyanobacterial remediation of cadmium-contaminated soil with rice husk biochar: An eco-friendly approach.

Present study is aimed to evaluate the influence of earthworm (Eisenia fetida), Cyanobacteria (Cylindrospermum stagnale), and rice husk biochar (BC) on cadmium (Cd) detoxification in artificially contaminated soil. The Cd content was kept at 10 mg/kg in factorial design I, coupled with 2% and 0% BC. E.

Spirulina platensis mediated biosynthesis of Cuo Nps and photocatalytic degradation of toxic azo dye Congo red and kinetic studies.

The current research is designed to synthesis Copper oxide nanoparticles (CuO NPs) using Cyanobacterium in greener way. The NPs were synthesized using Spirulina platensis. The method is adopted for the less toxic, less cost and environment friendly method.

Bioremediation of ossein effluents using the filamentous marine cyanobacterium Cylindrospermum stagnale.

Wastewater containg proteinaceous ossein effluents are problematic to be treated. We studied the possibility to treat ossein effluents with the marine cyanobacterium strain Cylindrospermum stagnale. After optimizing the culture conditions of the bacterium, three different types of ossein effluents were tested: dicalcium phosphate (DCP), high total dissolved solids (HTDS) and low total dissolved (LTDS).

Bioremoval capacity of Co using Phormidium tenue and Chlorella vulgaris as biosorbents.

Microalgae sorbents are microalgae that have the potential to passively bind heavy metals/contaminants to their cellular structures in a process called biosorption. This study investigates the use of two species of microalgae to remove the toxic heavy metal cobalt from aqueous solution. Two microalgae isolates, Phormidium tenue and Chlorella vulgaris, were collected from the Wadi Hanifah Stream in Riyadh, the Kingdom of Saudi Arabia.

COVID-19 Pandemic Causing Depression in Different Sociodemographic Groups in Saudi Arabia.

COVID-19 disease was announced as a global pandemic in March 2020 by the World health organization (WHO). Saudi Arabia was among the first countries to enforce restriction measures such as closing schools, remote working, and a travel ban. We aim to evaluate the impact of the COVID-19 pandemic on people's depression in Saudi Arabia.

A review on metal-based nanoparticles and their toxicity to beneficial soil bacteria and fungi.

The unregulated deposition of metal-based nanoparticles in terrestrial ecosystems particularly in agricultural systems has alarmingly threatened the sustainability of the environment and diversity of beneficial microbial populations such as soil bacteria and fungi. This occurs due to the poor treatment of biosolids during wastewater treatment and their application in agricultural fields to enhance the fertility of soils. Continuous deposition, low biodegradability, and longer persistence of metal nanoparticles in soils adversely impact the population of soil beneficial bacteria and fungi.

Decolorization of acid blue 29, disperse red 1 and congo red by different indigenous fungal strains.

Azo dyes are toxic and recalcitrant environmental pollutants in wastewater and soil in many industrial sites in Asia and Arabic countries. The aim of this study was to find fungal species useful in wastewater treatment and soil remediation efforts. We assessed the ability of different indigenous Aspergillus strains (i.

Eco-friendly synthesis of silver nanoparticles by and their antibacterial activity.

was used for biogenic of silver nanoparticles. Characterization of the prepared silver nanoparticles was done by UV-Vis spectroscopy, Transmission Electron Microscopy (TEM), and Fourier Transform Infrared Spectroscopy (FT-IR). The particle size of the prepared nanoparticles ranges from 3 to 20 nm with spherical or roughly spherical forms.

Antimicrobial efficacy of Nocardiopsis sp. MK_MSt033 against selected multidrug resistant clinical microbial pathogens.

Background: Actinomycetes show an active role in microbial disease control and antimicrobial metabolism production and were shown the greatest potentialities as sources of antimicrobial agents. The past few decades, an extensive literature has accumulated on the production of bioactive compounds from actinomycetes, particularily genus Streptomyces.

Methods: The actinomycetes were isolated with starch casein nitrate (SCN) agar medium.

Gold nanoparticles synthesised by flavonoid tricetin as a potential antibacterial nanomedicine to treat respiratory infections causing opportunistic bacterial pathogens.

In this study, flavonoid tricetin was used as a reducing and capping agent for the synthesis of gold nanoparticles (AuNPs). Further, the antibacterial efficacy of the synthesised AuNPs was evaluated against the opportunistic bacterial pathogens that cause respiratory infections. The optimum levels for the synthesis of AuNPs were found to be pH 8, temperature 30 °C, tricetin 125 μM and chloroauric acid 250 μM.