The diagnostic value of whole-body HYNIC-PSMA 11 -Tc [Tc] SPECT/CT scan in early staging of patients with moderate- and high-risk prostate cancer.

Objective: This prospective study aims to compare the diagnostic yield of conventional imaging modalities, including CT scan, bone scan, with Tc-HYNIC-PSMA-11, in detecting local and distant metastases for initial staging in treatment-naïve, intermediate- to high-risk prostate cancer (PCa) patients.  Ga-PSMA or 18F-PSMA PET/CT scans are known as the preferred modalities for staging this kind of patients, but there are limited PET/CT facilities in developing countries.

Materials And Methods: A total of 63 treatment-naïve PCa patients were included in the study for the initial staging.

effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury.

Objectives: Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induced AKI Wistar rats and evaluating their significance in AKI treatment.

Different methods to determine the encapsulation efficiency of protein in PLGA nanoparticles.

Background: Effective encapsulation of drugs into the delivery systems could increase the efficiency of nanoparticles in prevention and treatment of diseases.

Objective: The purpose of this study was to compare the different methods for determination of encapsulation efficiency of a model protein in the PLGA nanoparticles.

Methods: The various direct methods include dichloromethane, acetonitrile, modified acetonitrile and NaOH based extraction and radioactive methods were used to directly calculate the encapsulation efficiency of the loaded protein in the PLGA nanoparticles.

Strong enhancement of cage effects in water photolysis caused by interatomic Coulombic decay.

The impact of the solvent on the photodissociation of embedded molecules has been intensively investigated in the last decades. Collisions of photofragments with the solvating atoms or molecules can change their kinetic energy distribution or even lead to the de-excitation of the dissociating molecule to a bound electronic state quenching the dissociation. In this article we show that this cage effect is strongly enhanced if interatomic Coulombic decay (ICD) of the excited state becomes allowed.

Rovibrational spectroscopy using a kinetic energy operator in Eckart frame and the multi-configuration time-dependent Hartree (MCTDH) approach.

For computational rovibrational spectroscopy the choice of the frame is critical for an approximate separation of overall rotation from internal motions. To minimize the coupling between internal coordinates and rotation, Eckart proposed a condition ["Some studies concerning rotating axes and polyatomic molecules," Phys. Rev.

Diagnostic value of 99mTc-bombesin scintigraphy for differentiation of malignant from benign breast lesions.

Objective: In this study, we evaluated the diagnostic accuracy of (99m)Tc-bombesin scintigraphy for differentiation of benign from malignant palpable breast lesions. (99m)Tc-Bombesin is a tracer with high affinity for gastrin-releasing peptide receptor, which is overexpressed on a variety of human tumors including breast carcinoma.

Materials And Methods: We examined 33 consecutive women who were referred to our center with suspicious palpable breast lesions but had no definitive diagnosis in other imaging procedures.

Full-dimensional MCTDH/MGPF study of the ground and lowest lying vibrational states of the bihydroxide H3O2(-) complex.

In this study, we present a full-dimensional (9D) quantum dynamical analysis of the lowest vibrational eigenstates of H3O2(-). We have made use of the Multiconfiguration Time-Dependent Hartree method in conjunction with both an analytical and a numerical representation of the Kinetic Energy Operator and the newly developed Multigrid POTFIT [D. Peláez, H.

Numeric kinetic energy operators for molecules in polyspherical coordinates.

Generalized curvilinear coordinates, as, e.g., polyspherical coordinates, are in general better adapted to the resolution of the nuclear Schrödinger equation than rectilinear ones like the normal mode coordinates.

Radioimmunotherapy of MCF7 breast cancer cell line with 131I-PR81 monoclonal antibody against MUC1: comparison of direct and indirect radioiodination methods.

PR81 is a monoclonal antibody that binds with high affinity to MUC1, which is over expressed on breast and other tumors. The objective of this study was to compare the two labeling methods (direct and indirect radioiodination) for application of this antibody against MUC1 as a radioimmunotherapeutical agent.Monoclonal antibody (PR81) against the tandem repeat of the core protein (MUC1) was prepared, characterized, purified, and labeled with 131I using the direct (chloramin-T) and indirect (Fmoc-D-Tyr (tBu)-D-Tyr (tBu)-D-Lys (Boc)-OH (YYK) attached to N-hydroxysuccinimide as a linker between PR81 and 131I) methods.