Publications by authors named "Kewin Panel"
Background: Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available.
Methods: The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic HES [HES-L], neoplastic HE/HES [HE/HES-N], HE of unknown significance [HE-US], as well as IgG4-related disease [IgG4RD] or ANCA-negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps).
Comparison of the Alinity M STI with the GeneXpert CT/NG for the detection of sexually transmitted microorganisms.
Diagn Microbiol Infect Dis
March 2024
We assess the performances of the Alinity M STI assay (Abbott Molecular) in comparison to the Xpert CT/NG assay (Cepheid). We first retrospectively used a collection of 70 frozen samples of which 33, 31, and 6 were positives for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), and both micro-organisms respectively. The Alinity M STI and the Xpert CT/NG results were in accordance for all.
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- Eosinophilia, a condition marked by high eosinophil levels in the blood, can be significant in ICU patients but has been understudied regarding its causes and implications.
- In a study of 620 ICU patients over 6 years, two groups based on the timing of eosinophilia were identified: early (within 24 hours) and delayed (after 24 hours), with varying causes and symptoms.
- The survival rates at 60 days post-admission were similar for both groups, and specific risk factors related to mortality were identified, highlighting the need for tailored management approaches based on the timing of eosinophilia onset.
Recurrent cardiac arrest due to eosinophilia-related coronary vasospasm successfully treated by benralizumab.
J Allergy Clin Immunol Pract
September 2021
Eosinophils have widespread procoagulant effects. Eosinophilic cardiovascular toxicity mostly consists of endomyocardial damage or eosinophilic vasculitis, while reported cases of venous thrombosis (VT) are scarce. We aimed to report on the clinical features and treatment outcomes of patients with unexplained VT and eosinophilia, and to identify predictors of relapse.
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- FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare condition with limited epidemiological data; a retrospective study analyzed 151 patients in France from 2003-2019.
- Imatinib mesylate (IM) is very effective, with 98% of treated patients achieving complete hematologic and molecular responses; however, a significant percentage of patients relapsed after stopping IM.
- Factors such as the timing of IM initiation and duration of treatment were identified as independent predictors of relapse, suggesting that early and prolonged treatment may help reduce the chances of relapse.