Leveraging User-Centered Design and Usability and Skills Testing for a Novel Diabetes Survival Skills Toolkit.

Purpose: With the expansion of telemedicine, patient-centered approaches for delivering diabetes mellitus (DM) self-care education in both in-person and remote settings are needed. A novel Diabetes Survival Skills Toolkit (Kit) (physical toolkit, website, paper guide) was developed, using a user-centered design approach. The aim of this study was to develop a hybrid protocol to assess the perceived usability of the Kit and the skills attainment of its users.

Aquaporins: New players in breast cancer progression and treatment response.

Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport water and other small molecules and ions following an osmotic gradient across cell plasma membranes. This enables them to regulate numerous functions including water homeostasis, fat metabolism, proliferation, migration, and adhesion. Previous structural and functional studies highlight a strong biological relationship between AQP protein expression, localization, and key biological functions in normal and cancer tissues, where aberrant AQP expression correlates with tumorigenesis and metastasis.