Phase variation in challenges the static genome paradigm.

is a key agent in bovine respiratory disease (BRD), driving antibiotic use in feedyard cattle. As a facultative anaerobe commonly found in the upper respiratory tracts of cattle, its role under anaerobic conditions in BRD has not been extensively studied despite the known importance of anaerobiosis in human respiratory infections. Utilizing a combined omics approach, we refuted the null hypothesis that the genome sequence is independent of the environment.

A novel approach for detecting strains frequently attributed to human illness-development and validation of the highly pathogenic (HPS) multiplex PCR assay.

Introduction: Non-typhoidal (NTS) are leading bacterial agents of foodborne illnesses and a global concern for human health. While there are over 2,600 different serovars of NTS, epidemiological data suggests that certain serovars are better at causing disease than others, resulting in the majority of reported human illnesses in the United States. To improve food safety, there is a need to rapidly detect these more pathogenic serovars to facilitate their removal from the food supply.

A Conserved Histophilus somni 23S Intervening Sequence Yields Functional, Fragmented 23S rRNA.

Histophilus somni is a Gram-negative bacterial organism that acts as an opportunistic pathogen and is a fastidious member of the family associated with diseases of respiratory, reproductive, cardiac, and other tissues of ruminants. We identified an intervening sequence (IVS) embedded in all five copies of the 23S rRNA gene in the closed genome sequence of the H. somni isolate USDA-ARS-USMARC-63250 that may play an important role in affecting the biology of the organism.