Whole-genome analysis of NDM-producing associated with recurrent bacteraemia with rapid development of aztreonam-avibactam resistance.

A 60-year-old male with recurrent bacteremia associated with necrotizing pancreatitis was followed over 17 months, during which six clinical isolates of were obtained. The index isolate (R1) was susceptible to aztreonam-avibactam (MIC 4 mg/L), but resistance (MIC >64 mg/L) emerged with isolate B1, collected one month later, and persisted in subsequent isolates. To investigate the genomic and phenotypic evolution of six clinical isolates, focusing on mechanisms underlying the emergence of aztreonam-avibactam resistance.

Aztreonam-avibactam resistance rates and resistance mechanisms of NDM and NDM/OXA48-like dual-carbapenemase-producing Enterobacterales in Singapore.

Aztreonam-avibactam is a treatment option for metallo-β-lactamase carbapenemase-producing Enterobacterales (CPE). This study was performed to determine resistance rates of a collection of CPE against aztreonam-avibactam and characterise associated resistance mechanisms. Minimum inhibitory concentrations (MICs) of a collection of New Delhi metallo-β-lactamase (NDM)- and NDM/OXA-48-like dual-CPE isolates were determined using two methods, the MIC Test Strip (MTS) and broth microdilution (Sensititre).

chorioamnionitis associated with preterm delivery: A case report.

This case report highlights a infection associated with chorioamnionitis following preterm premature rupture of membranes (PPROM) in a 43-year-old pregnant woman at 30 weeks gestation. The patient presented with a mild fever and increased white cell count, leading to the diagnosis of chorioamnionitis. Empiric antibiotic treatment with ampicillin and gentamicin was initiated, later switched to ceftriaxone.

Genotypic diversity and antimicrobial resistance phenotype of carbapenem-resistant and carbapenem-susceptible Acinetobacter species isolates.

Members of the Acinetobacter baumannii complex are common nosocomial pathogens with propensity for developing carbapenem resistance. Much emphasis is placed on carbapenem-resistant Acinetobacter baumannii (CRAB), although carbapenem-susceptible Acinetobacter baumannii (CSAB) isolates also cause serious infections. Genomic and phenotypic differences between these isolates are analysed in this study.