Association of Cytokines in Breast Milk with Otitis Media Infection and Fever Frequency in Infants: A Case-Control Study.

Infants have an immature immune system, making them more susceptible to infectious diseases, including otitis media (OM). Breastfeeding is known to reduce OM risk. Although cytokines in breast milk regulate immune functions, their association with OM incidence is underexplored.

Strontium and barium in deciduous teeth and infant feeding methods: A birth cohort adjunct study to the Japan environment and children's study.

Deciduous teeth are a unique medium that record exposure to various elements over time, as they are formed during fetal and infantile periods. We aimed to evaluate the association between infant feeding methods and changes in the distribution of Barium (Ba) and Strontium (Sr) in deciduous teeth of children. The current analysis included 216 children around 6-7 years of age whose deciduous central incisor teeth were provided between March 2018 and February 2020, as an adjunct study of the Japan Environment and Children's study.

[A Case of Thyroid Cancer Discovered Incidentally after Breast Cancer Surgery].

The patient was a 51-year-old woman. A left breast tumor was detected during a health checkup and the patient was referred to our hospital. Upon arrival, a mobile mass measuring 17 mm in diameter was palpable in the CD region of the left breast.

Association Between Maternal Dietary Isoflavone Intake During Pregnancy and Childhood Allergic Rhinoconjunctivitis: The Japan Environment and Children's Study.

Isoflavone (ISO) may have immunosuppressive and promoting effects. In this study, we aimed to examine the association between maternal dietary ISO intake during pregnancy and childhood allergic rhinoconjunctivitis at the age of 3 years using the Japanese Birth Cohort data. : Overall, 78,549 mother-child pairs were studied.

[pT2 Gallbladder Cancer with Suspected Intrapancreatic Bile Duct Recurrence Four Years Postoperatively-A Case Report].

We report a case of intrapancreatic bile duct solitary recurrence 4 years postoperatively for pT2 gallbladder cancer. A 58-year-old woman underwent laparoscopic cholecystectomy for a growing gallbladder polyp. Her histopathological findings included well-differentiated adenocarcinoma, pT2a, ly0, v0, ne0, pCM0, pEM0, R0.

[A Case of Breast Pleomorphic Invasive Lobular Carcinoma with Difficulty in Preoperative Diagnosis].

Invasive lobular carcinoma of the breast is on the rise. Among lobular carcinomas, pleomorphic invasive lobular carcinoma is considered to be a highly malignant subgroup. The patient was a 38-year-old woman.

The effects of mother-infant bonding on children's strengths and difficulties.

Background: Several studies have shown that parental relationships between infants and their caregivers, and their mental health condition in childhood, influence children's development. The present study aimed to predict the effects of maternal mental health and mother-infant bonding at 10 months of age on Japanese children's behavioral development at 5 years. We analyzed factors including maternal mental health and mother-infant bonding to predict subtype classes as a prospective cohort study.

Aspirin promotes odontogenic differentiation via a mechanism involving FOXC1, RUNX2, and MCAM expression.

Objectives: This study aimed to investigate the effects of aspirin on the early stages of odontogenic differentiation. The roles of FOXC1, RUNX2, and MCAM gene expression in the mechanism of odontogenic differentiation were evaluated by examining the effects of downregulated FOXC1 or RUNX2 expression using small interfering RNAs (siRNAs).

Methods: Dental pulp cells were treated with aspirin (0, 2.

Effects of the SGLT2 inhibitor ipragliflozin and metformin on hepatic steatosis and liver fibrosis: Sub-analysis of a randomized controlled study.

Aims: To compare the effects of ipragliflozin, a sodium-dependent glucose transporter-2 inhibitor, and those of metformin on the visceral fat area (VFA), a prospective, multi-centre, open-label, blinded-endpoint, randomized, controlled study was undertaken. The generated data were used to examine the effects of ipragliflozin and metformin on indices of hepatic steatosis and liver fibrosis.

Materials And Methods: In total, 103 Japanese patients with type-2 diabetes (T2D), body mass index (BMI) of ≥22 kg/m and glycated haemoglobin level of 7%-10% were randomly administered ipragliflozin 50 mg or metformin 1000 mg for 24 weeks.

Association Between Antibiotic Exposure During Pregnancy and Postpartum Depressive Symptoms: The Japan Environment and Children's Study.

Postpartum depressive symptoms (PDS) are a common mental health condition among women after delivery. Although various causative factors have been reported, PDS remains a challenging condition to predict and prevent. The disruption of the gut microbiota due to antibiotic exposure has been reported to affect psychiatric conditions.

Risk of autism spectrum disorder at 18 months of age is associated with prenatal level of polychlorinated biphenyls exposure in a Japanese birth cohort.

Prenatal exposure to polychlorinated biphenyls (PCBs) has a detrimental effect on early cognitive development. Based on these observations, some researchers suggested that prenatal exposure to PCB may be an environmental cause of autism spectrum disorder (ASD). To investigate the potential link between prenatal exposure to PCB, we analyzed the link between the level of prenatal PCB exposure and ASD risk evaluated at 18 months of age and behavioral problems at 5 years old based on longitudinal birth cohort data collected in urban areas in Japan based on the data from 115 mother-infant pairs.

Three-year Seroprevalence of SARS-CoV-2 Nucleocapsid Protein Antibody Among Children, Parental Awareness, and Contributors of Infection: A Single-school Cohort Study in Chiba, Japan.

Background: Coronavirus disease 2019 (COVID-19) in children is often asymptomatic, posing challenges in detecting infections. Additionally, factors contributing to infection remain poorly understood. This study aimed to investigate trends in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid antibody seroprevalence, the relationship between seroprevalence and parental perception of child infection, and factors related to COVID-19 in children.

Second phase Chiba study of mother and child health (C-MACH): Japanese birth cohort study with multiomics analyses.

Purpose: Epidemiological studies have reported that environmental factors from fetal period to early childhood can influence the risk of non-communicable diseases in adulthood. This concept has been termed the developmental origins of health and disease (DOHaD). The Chiba study of Mother and Child Health (C-MACH) is a DOHaD concept-based birth cohort study which started in 2014.

[Long-Term Response to CDK4/6 Inhibitor for Multiple Metastases of Breast Cancer].

The patient was a 60-year-old woman. She was diagnosed with hypertension, symptomatic epilepsy, renal failure, and cerebral infarction. During follow-up, she was found to have a mass in her left breast and was referred to our department.

[A Case of Ectopic Mediastinal Goiter Developed during Administration of Rheumatrex].

We report a case of ectopic goiter that developed during administration of rheumatrex and in which we had difficulty in differentiating it. A 46-year-old woman had been diagnosed with rheumatoid arthritis(RA) and had been taking rheumatrex(12.5 mg/week)for the past 2 years.

[Encapsulated Papillary Carcinoma and Mucinous Carcinoma in a Case of Locally Advanced Bilateral Breast Cancer].

We report encapsulated papillary carcinoma and mucinous carcinoma in a case of local advanced bilateral breast cancer. The patient was 78-year-old woman who had bilateral breast tumor. The right palpable tumor was 6 cm in diameter and left tumor was 7 cm in a diameter.

Elucidation of endogenous and exogenous chemicals in maternal serum using high-resolution mass spectrometry.

The increasing exposure to environmental chemicals calls for comprehensive non-targeted analysis to detect unrecognized substances in human samples. We examined human serum samples to classify compounds as endogenous or exogenous using public databases and to explore the relationships between exposure markers and metabolic patterns. Serum samples from 84 pregnant women at 32 weeks gestation were analyzed using LC-QToFMS.

Associations of Parental Education With Children's Infectious Diseases and Their Mediating Factors: The Japan Environment and Children's Study (JECS).

Background: Parents' educational background is presumed to influence the incidence of vaccine-preventable diseases in children through their decisions about vaccinations and other family lifestyle choices. Regarding voluntary vaccination, a household's economic situation may also be associated with non-vaccination. Therefore, this study investigated the association between parental education and vaccine-preventable diseases (varicella, mumps, influenza [flu], pertussis, measles, and rubella) in children, which currently remains elusive.

Integrating multi-wet laboratory diagnostics to study staphylococci in animals in Uganda.

Background: Several diagnostic environments in Uganda lack real-time, robust and high-throughput technologies for comprehensive typing of microbes, which is a setback to infectious disease surveillance. This study combined various wet laboratory diagnostics to understand the epidemiology of pathogenic staphylococci isolated from animals in Uganda and the implications for global health security priorities.

Methods: A retrospective study was conducted employing records and pathogenic staphylococci (from animals) archived at the Central Diagnostic Laboratory (CDL), Makerere University, Uganda, between January 2012 and December 2019.

Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women.

One-carbon metabolism (OCM) is a complex and interconnected network that undergoes drastic changes during pregnancy. In this study, we investigated the longitudinal distribution of OCM-related metabolites in maternal and cord blood and explored their relationships. Additionally, we conducted cross-sectional analyses to examine the interrelationships among these metabolites.

Characteristics of cadence during continuous walking in daily life.

Despite the acknowledged relationship between the usual (preferred) walking speed (UWS) and health, there is currently no practical method available to reliably and accurately detect slight changes in UWS. This study aimed to explore whether either of the following two phenomena occurs during continuous daily walking in various periods: (a) Similarity between the most frequent cadences in the two periods. (b) The occurrence of the most frequent cadence in at least one of the two periods during the other period, with a frequency close to that of the most frequent cadence.

Association between maternal blood or cord blood metal concentrations and catch-up growth in children born small for gestational age: an analysis by the Japan environment and children's study.

Background: Catch-up growth issues among children born small for gestational age (SGA) present a substantial public health challenge. Prenatal exposure to heavy metals can cause adverse effects on birth weight. However, comprehensive studies on the accurate assessment of individual blood concentrations of heavy metals and their effect on the failure to achieve catch-up growth remain unavailable.

[Permissibility of Stoma Closure Surgery in Patients with Colorectal Cancer Who Underwent Primary Tumor Resection Including in Cancer-Bearing Conditions].

From 2006 to 2021, 27 patients who underwent stoma construction during colorectal cancer resection followed by stoma closure were grouped into 2 groups: Group A(7 patients with cancer)and Group B(20 patients without cancer). The male- to-female ratio were 6:1 for Group A and 13:7 for Group B. The average ages were 63.