Publications by authors named "Keiko Kajiya"
Article Synopsis
- The study investigates the early stages of tumor development, specifically focusing on lung adenocarcinomas like adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma.
- Researchers conducted comprehensive genomic analysis on 76 lung cancer samples, combining sequencing data with transcriptomic and epigenomic information.
- Findings indicate that very early-stage tumors have minimal somatic mutations, primarily in key driver mutations, leading to copy number changes and global DNA hypomethylation as the disease progresses, particularly in Noguchi type B tumors.
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.
Biochem Biophys Res Commun
May 2007
MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B.
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