Automated insulin delivery for safe fasting and exercise during Ramadan in patients with type 1 diabetes: The active fast study.

Aims: To evaluate the safe and effective use of the MiniMed™ 780G Advanced Hybrid Closed-Loop system (AHCLS) in adults with type 1 diabetes mellitus (T1DM) during Ramadan fasting combined with structured Moderate-Intensity Exercise (MIE) followed by the non-fasting month (Shawwal) with continued MIE.

Methods: This prospective, single-arm interventional study recruited 34 adults with T1DM using the MiniMed™ 780G. Participants performed MIE during non-fasting hours in Ramadan and continued it in Shawwal.

Advanced Hybrid Closed-Loop Insulin Delivery Is Associated With Improved Glycemic Indicators and Normalization of Small Nerve Fibre Structure in Adults With Type 1 Diabetes.

Background: Hyperglycemia is a major driver of diabetic peripheral neuropathy (DPN) in type 1 diabetes mellitus (T1DM). Advanced hybrid closed-loop (AHCL) technologies improve glycemic control and reduce glycemic variability and may improve DPN.

Methods: Patients with T1DM treated for 9.