Publications by authors named "Katherine Hemsworth"
Centrioles have a unique, conserved architecture formed by three linked, 'triplet', microtubules arranged in ninefold symmetry. The mechanisms by which these triplet microtubules are formed remain unclear but likely involve the noncanonical tubulins delta-tubulin and epsilon-tubulin. Previously, we found that human cells lacking delta-tubulin or epsilon-tubulin form abnormal centrioles, characterized by an absence of triplet microtubules, lack of central core protein POC5, and a futile cycle of centriole formation and disintegration (Wang et al.
View Article and Find Full Text PDFPurpose: To assess longitudinal reproducibility of metrics of foveal density (peak cone density [PCD], cone density centroid [CDC], and 80th percentile centroid area) in participants with normal vision.
Methods: Participants (n = 19; five male and 14 female) were imaged at two time points (average interval of 3.2 years) using an adaptive optics scanning light ophthalmoscope (AOSLO).
Article Synopsis
- The study aimed to analyze how sensitive different quantitative metrics of retinal blood vessels are when using optical coherence tomography angiography (OCT-A) images.
- Full retinal images from 94 healthy individuals were used to simulate capillary loss, with various metrics calculated to assess sensitivity to this loss.
- Results showed that commonly used metrics like foveal avascular zone (FAZ) area and vessel density were not effective at detecting capillary loss until significant loss occurred, highlighting the need for further research to understand different loss patterns and improve metric reliability.