Publications by authors named "Katharina Eiseler"
Genetic and functional analysis of chymotrypsin-like protease (CTRL) in chronic pancreatitis.
Pancreatology
December 2023
Article Synopsis
- Genetic predisposition is significant for early-onset chronic pancreatitis (CP), with some cases linked to genetic changes in digestive enzyme genes, while others remain unexplained.
- Researchers investigated CTRL, a chymotrypsin-like protease, by screening over 1,000 CP patients and 1,500 controls for genetic variants, analyzing their effects on enzyme secretion and activity.
- Although several CTRL variants were identified, many did not impact function or were equally present in both patients and controls, suggesting that CTRL is probably not a major contributor to the development of CP.
Article Synopsis
- - Researchers studied the potential role of genes AQP12A and AQP12B in chronic pancreatitis (CP) since many non-alcoholic CP cases lack known genetic mutations.
- - DNA sequencing of these genes in 292 CP patients and 143 controls revealed 41 genetic changes, but no significant differences in variants between patient and control groups.
- - The findings indicate that alterations in AQP12A and AQP12B are not linked to the risk of developing non-alcoholic CP, suggesting AQP12B may not be essential for normal pancreatic function.
Background: The calcium sensing receptor (CASR) is a G protein-coupled receptor that is responsible for assessing extracellular Ca levels and thus plays a crucial role in calcium homeostasis. Hypercalcemia is a metabolic risk factor for pancreatitis and rare CASR variants have been described in patients with chronic pancreatitis. At the carboxy-terminal tail of CASR, there is a cluster of three common polymorphisms, p.
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