Improving Result Turnaround Time as a Crucial Factor to Increasing Clozapine Therapeutic Drug Monitoring in Hospitalized Patients.

Purpose/background: Clozapine requires careful monitoring to minimize adverse reactions and optimize response. Because of variable pharmacokinetics and interpatient variability, guidelines recommend therapeutic drug monitoring (TDM), although practical guidance is limited. This study aims to characterize patient factors associated with TDM, rates of TDM use over time, turnaround times of TDM results, and influence of institutional initiatives aimed to improve TDM.