The Impact of Therapeutic Drug Monitoring on Clozapine Dosing and Clinical Outcome in a Tertiary Care Center in India: A Retrospective Study.

Background: There are significant interindividual and interethnic variations in serum clozapine levels achieved for a particular dose of clozapine. Therapeutic drug monitoring (TDM) helps optimize the clozapine dosing. We studied the impact of TDM on clozapine dosing and clinical outcomes in subjects with treatment-resistant schizophrenia.

Unmasking bipolarity in recurrent depressive disorder following herpes simplex virus triggered n-methyl-D-aspartate encephalitis.

Objective: Herpes simplex virus (HSV) infection triggered n-methyl-D-aspartate (NMDA) encephalitis can lead to varied neuropsychiatric manifestations, including movement disorders and manic symptoms. HSV is known to affect the same brain regions as in secondary mania.

Method: We present a 35-year-old female diagnosed with recurrent depressive disorder (RDD) who developed NMDA encephalitis triggered by HSV infection.