Association Between Small Vessel Disease and Migraine: A Study Based on Peak Width of Skeletonized Mean Diffusivity.

Background And Purpose: Migraine is a common neurological disorder associated with structural and functional brain changes, while small vessel disease (SVD) is the leading cause of white matter damage in older adults. Diffusion tensor imaging (DTI) is effective for assessing white matter, and the peak width of skeletonized mean diffusivity (PSMD) is a novel marker for such damage. No study has used PSMD to assess SVD in migraine patients.

White matter alterations in cluster headache identified using PSMD analysis.

This study aimed to investigate white matter microstructural changes in patients with cluster headaches using peak width of skeletonized mean diffusivity (PSMD) derived from diffusion tensor imaging (DTI). A total of 40 participants were recruited, comprising 20 patients with newly diagnosed cluster headaches and 20 healthy controls. DTI was conducted using a 3 Tesla MRI scanner.

Analysis of functional brain connectivity in patient with end-stage kidney disease undergoing peritoneal dialysis using functional near infrared spectroscopy.

Introduction: Neurological complications are common in patients with end-stage kidney disease (ESKD). However, the mechanisms underlying neurological complications of ESKD are poorly understood. Research on brain connectivity in patients undergoing peritoneal dialysis (PD) is limited.

Choroid plexus enlargement in patients with rapid eye movement sleep behavior disorder: relevance to glymphatic system dysfunction.

Choroid plexus volume change has been suggested as a biomarker for the course of various neurological diseases. However, its role in sleep disorders remains unclear. We analyzed choroid plexus volume changes in patients with isolated rapid eye movement sleep behavior disorder (iRBD) compared with healthy controls.

Altered intrinsic thalamic network based on electroencephalography source-level analysis in poststroke epilepsy.

This study aimed to investigate the alterations in the intrinsic thalamic network in patients with poststroke epilepsy (PSE) based on electroencephalography (EEG) source-level analysis. This retrospective observational study followed the STROBE guidelines. Thirty-nine patients with stroke and PSE and 34 patients with stroke without PSE were enrolled.

Structural brain network metrics as novel predictors of treatment response in restless legs syndrome.

Objective: This study aimed to investigate morphometric similarity networks in patients with newly diagnosed restless legs syndrome (RLS) compared with healthy controls and to examine their relationship with treatment response.

Methods: A total of 49 patients with newly diagnosed RLS and 58 healthy controls were prospectively enrolled. Brain magnetic resonance imaging was performed using a 3-T scanner, and morphometric similarity network analysis was conducted on T1-weighted images.

Small-vessel-disease-induced white matter damage in occipital lobe epilepsy.

Background: Peak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease. This study aimed to investigate the presence of small vessel disease in patients with occipital lobe epilepsy (OLE) using PSMD.

Methods: We enrolled 27 patients newly diagnosed with OLE and included 29 healthy controls.

White matter changes in patients with narcolepsy type 2: Peak width of skeletonized mean diffusivity study.

Objectives: This study aimed to investigate white matter (WM) microstructural alterations in patients with narcolepsy type 2 (NT2) using Peak Width of Skeletonized Mean Diffusivity (PSMD), a novel imaging marker associated with small vessel disease (SVD). The study compared PSMD metrics between patients with NT2 and healthy controls to investigate structural disruptions and their implications for NT2 pathophysiology.

Methods: A total of 42 participants were enrolled, including 20 patients with newly diagnosed NT2 and 22 healthy controls.

Choroid Plexus Enlargement in Patients with Chronic Migraine: Implications for Glymphatic System Dysfunction.

Objectives: The choroid plexus produces cerebrospinal fluid, which is crucial for glymphatic system function. Evidence suggests that changes in the volume of the choroid plexus may be associated with glymphatic system function. Therefore, this study aimed to investigate alterations in choroid plexus volume in patients with migraines compared with healthy controls.

Brain MRI Detection of an Abnormal Peak Width of Skeletonized Mean Diffusivity in REM Sleep Behavior Disorder.

Background And Purpose: Peak width of skeletonized mean diffusivity (PSMD) is a novel marker of white matter damage, which may be related to small vessel disease. This study aimed to investigate the presence of white matter damage in patients with isolated rapid eye movement sleep behavior disorder (RBD) using PSMD.

Methods: We enrolled patients with newly diagnosed isolated RBD confirmed by polysomnography and age- and sex-matched healthy controls.

Multilayer network analysis in patients with end-stage kidney disease.

This study aimed to investigate alterations in a multilayer network combining structural and functional layers in patients with end-stage kidney disease (ESKD) compared with healthy controls. In all, 38 ESKD patients and 43 healthy participants were prospectively enrolled. They exhibited normal brain magnetic resonance imaging (MRI) without any structural lesions.

Evidence of small vessel disease in patients with juvenile myoclonic epilepsy based on the peak width of skeletonized mean diffusivity.

Objectives: Peak width of skeletonized mean diffusivity (PSMD) is a novel marker of white matter changes probably due to small vessel disease. This study aimed to investigate the presence of white matter changes in juvenile myoclonic epilepsy (JME) using PSMD.

Methods: We enrolled patients with JME and age- and sex-matched healthy controls.

Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis.

Objective: White matter abnormalities in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) are well known. Peak width of skeletonized mean diffusivity (PSMD) is a novel marker for quantifying white matter integrity that may reflect small vessel disease. In this study, we aimed to quantify the extent of white matter damage in patients with TLE and HS by using PSMD.

The association between small vessel disease and obstructive sleep apnea: a peak width of skeletonized mean diffusivity-based study.

Purpose: Peak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease in the brain. This study aimed to investigate the association between small vessel disease and obstructive sleep apnea (OSA) using PSMD.

Methods: We enrolled patients with OSA and age- and sex-matched healthy controls, and performed diffusion tensor imaging (DTI) using a 3-tesla MRI scanner in them.

Choroid plexus enlargement in patients with end-stage renal disease: implications for glymphatic system dysfunction.

Objectives: The choroid plexus plays a role in eliminating detrimental metabolites from the brain as an integral component of the glymphatic system. This study aimed to investigate alterations in choroid plexus volume in patients with end-stage renal disease (ESRD) compared with healthy controls.

Methods: We enrolled 40 patients with ESRD and 42 healthy controls.

Choroid plexus volumes in patients with transient global amnesia: A retrospective study.

Increased choroid plexus (ChP) volume is well known to be associated with glymphatic system dysfunction. This study aimed to investigate glymphatic system function in patients with transient global amnesia (TGA) compared to healthy controls through ChP volumes measurements. We retrospectively enrolled patients with TGA from our hospital, as well as healthy controls.

Effect of glymphatic system function on cognitive function in patients with chronic kidney disease.

Objectives: Studies have recently shown an alteration of the structural connectivity and a dysfunctional glymphatic system in patients with chronic kidney disease (CKD). In this study, we aimed to investigate the effects of the structural connectivity and glymphatic system on the cognitive function of patients with CKD.

Methods: We prospectively enrolled patients with CKD and healthy controls.

Effect of Dialysis on Structural Brain Connectivity in Patients with End-Stage Renal Disease.

Introduction: Patients with end-stage renal disease (ESRD) are known to have reduced structural and functional brain connectivity in the brain regions associated with cognitive function. However, the effect of dialysis on brain connectivity remains unclear. This study aimed to evaluate the effects of dialysis on structural brain connectivity in patients with ESRD.

Analysis of prefrontal cerebral blood volume and flow changes in ESKD patients undergoing hemodialysis using functional near-infrared spectroscopy.

Background: End-stage kidney disease (ESKD) patients undergoing hemodialysis experience diverse neurological complications. This study investigated prefrontal cerebral blood volume (CBV) and cerebral blood flow (CBF) during hemodialysis using functional near-infrared spectroscopy (fNIRS) to analyze cerebral hemodynamic changes.

Methods: ESKD patients undergoing maintenance hemodialysis without a history of neurological disorders were enrolled prospectively.

Alterations in functional brain connectivity following treatment for restless legs syndrome: The role of symptom improvement in restoring functional connectivity.

The pathophysiology of restless legs syndrome (RLS) remains incompletely understood. Although several studies have investigated the alterations of brain connectivity as one of the pathophysiological mechanisms of RLS, there are only few reports on functional connectivity changes after RLS treatment. Forty-nine patients with newly diagnosed RLS and 50 healthy controls were prospectively enrolled.

Choroid plexus enlargement in patients with obstructive sleep apnea.

Objectives: The function of choroid plexus is to produce cerebrospinal fluid, which is critical for the glymphatic system function. In this study, we aimed to analyze the differences in choroid plexus volume between patients with obstructive sleep apnea (OSA) and healthy controls, with the goal of discovering the glymphatic system dysfunction in patients with OSA.

Methods: We prospectively enrolled 40 patients with OSA confirmed by polysomnography and 38 age- and sex-matched healthy controls.