Publications by authors named "Kameliya Roegner"
Beyond hemoglobin: Critical role of 2,3-bisphosphoglycerate mutase in kidney function and injury.
Acta Physiol (Oxf)
January 2025
Article Synopsis
- The study explores the role of 2,3-bisphosphoglycerate mutase (BPGM) in the kidney, highlighting its upregulation during acute kidney injury in both mice and humans.
- Using a specialized mouse model, researchers found that BPGM is mainly located in the distal nephron and its knockout led to rapid kidney injury and structural damage after just four days.
- The absence of BPGM disrupts crucial metabolic processes, elevating oxidative stress and inflammation while linking stress responses between different parts of the nephron, underscoring its importance in kidney function.
Prolyl hydroxylase inhibitors, polydrug use, and the phosphoproteome.
Acta Physiol (Oxf)
January 2023
Article Synopsis
- Chronic Cyclosporine-A treatment can lead to severe side effects like kidney toxicity and anemia, potentially due to hypoxia.
- The study explored the effects of daprodustat, a hypoxia-inducible factor activator, on kidney toxicity caused by Cyclosporine-A, revealing that daprodustat significantly countered Cyclosporine-A's changes to protein expression and phosphorylation.
- While daprodustat alone had a minimal effect, its combination with Cyclosporine-A notably influenced angiogenesis-related pathways and prevented harmful impacts on blood hemoglobin levels and kidney microcirculation.