Medical and economic influence of the German hospital reform in 2024 on the hospitalisation and treatment of patients with odontogenic abscesses: the lessons learnt from the COVID-19 pandemic.

Introduction The COVID-19 pandemic significantly disrupted healthcare systems worldwide, including in Germany. This study investigated the impact of the pandemic on the management of dental abscesses and examined the implications for the upcoming German healthcare reform.Aims To assess how the COVID-19 pandemic affected hospitalisation, intensive care unit (ICU) admissions and treatment outcomes for dental abscesses, and to analyse the relationships between these findings and the German healthcare reform.

Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?

Background: Reasons for first using cannabis (RFUC) may influence later use patterns and mental health outcomes. However, limited research has explored self-medication versus social RFUCs in depth, and their associations with cannabis use patterns and psychopathology in the general population.

Objectives: We examined RFUCs and their associations with (1) reasons for continuing cannabis use, (2) weekly THC (delta-9-tetrahydrocannabinol) unit consumption and (3) symptoms of paranoia, anxiety and depressive symptoms.

The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach.

Background: Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay between childhood trauma, cannabis use, and paranoia using standard tetrahydrocannabinol (THC) units as a comprehensive measure of cannabis exposure.

Methods: Data were derived from the Cannabis&Me study, an observational, cross-sectional, online survey of 4,736 participants.

Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction.

Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus that causes seasonal epidemic respiratory infections, with novel subtypes of IAV historically able to lead to pandemics that spread on a global scale. We conducted a phenotypic high-throughput screen (HTS) that identified compound as a singleton hit. Resistant viral mutants generated against analog revealed mutations in the nucleoprotein (NP).