Ready, set, but no go: Skin fat comes preloaded with waiting precursors.

Fat depots across the body dynamically tune their sizes in response to nutrient demands and nonmetabolic cues. Writing in Cell Stem Cell, Rivera-Gonzalez et al. report that skin fat, notable for its ability to rapidly expand, harbors molecularly distinct precursors, primed for proliferation and differentiation into mature adipocytes.

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies.

Parkinson's disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of patients. Passive immunotherapy targeting these aggregates is an attractive disease-modifying strategy, which must not only demonstrate target selectivity towards α-Syn aggregates, but also achieve appropriate brain exposure to have the desired therapeutic effect. Here we present preclinical data for SAR446159, a next-generation antibody for the treatment of synucleinopathies.

A Wireless and Reusable OLED Patch for Accelerated In Vivo Skin Wound Healing.

A fully wireless and reusable red organic light-emitting diode (OLED) patch was developed as a noninvasive platform for skin wound phototherapy. The device integrates a USB-C rechargeable battery, a flexible printed circuit board, and a red OLED emitter into a soft, skin-conformal form factor. The OLED delivers uniform 645 nm light with minimal heat (∼21 °C) and stable radiance (21.

Efficacy and Safety of New Hyaluronic Acid Filler for Nasolabial Fold Correction: A Double-Blind, Randomized Trial.

Background: Nasolabial folds (NLFs) are a common cosmetic concern that makes people look older. Hyaluronic acid (HA)-based fillers are increasingly popular for minimally invasive facial wrinkle and fold correction. This study aimed to evaluate the efficacy and safety of a new monophasic HA filler, CUREA®, for NLF correction compared to the widely used Juvederm®.

Eye blinking characteristics as potential biomarkers in Isolated REM sleep behavior disorder during visuospatial attention tasks.

Introduction: Isolated REM sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies, such as Parkinson's disease (PD). Although altered eye blinking patterns are recognized as a clinical feature in PD, no studies have investigated its prodromal stage. This study aimed to investigate eye blinking characteristics in iRBD patients during a visuospatial attention task.

Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Background And Purpose: To evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS).

Methods: In this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS with an International Restless Legs Scale (IRLS) score ≥15 were randomized 1:1 to receive either pregabalin (=39) or placebo (=39) for 12 weeks. The primary efficacy outcome was the change in the IRLS score, and the secondary outcomes included the Clinical Global Impression-Improvement scale and changes in scores on other RLS symptom questionnaires.

User Experiences and Effects of Expert-Led YouTube Mind-Body Interventions on Insomniacs: A Survey Study.

Background: Behavioral and psychological therapies have been shown to be beneficial in insomnia treatment. YouTube, a video-based social media platform, has become the most widely used platform and is easily accessible to everyone. Therefore, this study investigated the effects of expert-led YouTube-delivered mind-body interventions (MBIs), including mindfulness, breathwork, and mental imagery, on sleep disturbance and user satisfaction.

A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibitor, in patients with mild to moderate atopic dermatitis: a proof-of-concept study with biomarker analysis.

Background: Current guidelines to treat atopic dermatitis (AD) overlook disease heterogeneity, limiting personalized care. This study assessed NuGel, a topical GPCR19 agonist, for efficacy, safety, and predictive baseline biomarkers in AD patients.

Methods: In a multicenter, double-blind, randomized, placebo-controlled Phase 2a trial (August 2020-September 2021, five hospitals, 80 participants), patients received placebo, 0.

Precise perivascular space segmentation on magnetic resonance imaging from Human Connectome Project-Aging.

Perivascular spaces (PVS) are cerebrospinal fluid-filled tunnels around brain blood vessels, crucial for the functions of the glymphatic system. Changes in PVS have been linked to vascular diseases and aging, necessitating accurate segmentation for further study. PVS segmentation poses challenges due to their small size, varying MRI appearances, and the scarcity of annotated data.

Changes in delayed sleep patterns and related clinical factors in a social restriction environment.

We aimed to investigate which factors, including socioenvironmental factors and emotional regulation, were associated with pronounced delayed sleep patterns during the COVID-19 social restriction. We evaluated 744 adults aged 20-65 y using a web-based survey with a self-reported questionnaire in May 2022. Based on the survey, we estimated the mid-sleep time on free days corrected for oversleeping on free days (MSFsc) and social jet lag (SJL).

Birth Outcomes of Infants Born to Mothers with Alopecia Areata: A Nationwide Population-based Study in Korea.

Data on pregnancy outcomes in patients with alopecia areata (AA) are limited. The aim of this study is to determine the association between maternal AA and risk of adverse birth outcomes in children. A retrospective cohort study was conducted on 45,328 children born to mothers with AA and 4,703,253 controls born to mothers without AA using the Korean National Health Insurance Claims database from 2002 to 2016.

Particulate Matter and Its Molecular Effects on Skin: Implications for Various Skin Diseases.

Particulate matter (PM) is a harmful air pollutant composed of chemicals and metals which affects human health by penetrating both the respiratory system and skin, causing oxidative stress and inflammation. This review investigates the association between PM and skin disease, focusing on the underlying molecular mechanisms and specific disease pathways involved. Studies have shown that PM exposure is positively associated with skin diseases such as atopic dermatitis, psoriasis, acne, and skin aging.

Artificial intelligence-based prescription of personalized scalp cosmetics improved the scalp condition: efficacy results from 100 participants.

Scalp-related symptoms such as dandruff and itching are common with diverse underlying etiologies. We previously proposed a novel classification and scoring system for scalp conditions, called the scalp photographic index (SPI); it grades five scalp features using trichoscopic images with good reliability. However, it requires trained evaluators.

A Case Report of Rubinstein-Taybi Syndrome Presenting with Extensive Keloid Formation and Review of Literature.

Rubinstein-Taybi syndrome (RSTS) is an extremely rare genetic disorder affecting multi-organ systems. A tendency to form keloid is one of the common dermatologic manifestations. We describe a 23-year-old female presented with extensive keloids which developed spontaneously.

Hereditary Leiomyomatosis and Renal Cell Cancer: A Case Report of Pilar Leiomyomatosis with History of Kidney Cancer and Review of the Literature.

Pilar leiomyoma or piloleiomyoma is a benign neoplasm of the smooth muscle arising from the arrector pili muscle. It manifests as brown to red firm papulonodules with sites of predilection being the face, trunk, and extensor surfaces of the extremities. Histologically, the lesions exhibit ill-defined dermal tumors with interlacing fascicles of spindle cells.

Needleless laser injector versus needle injection for skin enhancement and rejuvenation effect of dermal filler.

Background And Objectives: A needleless laser-induced microjet injector is a novel transdermal drug delivery system that can rapidly inject a very small and precise drug dose into the skin with minimal pain and downtime. In this study, we aimed to compare the laser-induced microjet injection versus needle injection of polylactic acid/hyaluronic acid filler for skin enhancement and rejuvenation.

Patients And Methods: A 24-week prospective, single-center, assessor-blinded, randomized, split-face study was conducted.

Comparison of Acceptance and Commitment Therapy (ACT) and Cognitive Behavior Therapy (CBT) for Chronic Insomnia: A Pilot Randomized Controlled Trial.

Purpose: Acceptance and Commitment Therapy (ACT) is part of the third wave of cognitive behavior therapy, and has six core components: acceptance, cognitive defusion, self as context, being present, values, and committed behavior. This study aimed to examine the efficacy of ACT for insomnia compared with cognitive behavior therapy for insomnia (CBT-I) in patients with chronic primary insomnia.

Methods: The study recruited patients with chronic primary insomnia from a university hospital between August 2020 and July 2021.

Guidelines for the Management of Patients with Alopecia Areata in Korea: Part II Systemic Treatment.

Background: Alopecia areata (AA) is a chronic disease with an unpredictable course and can have a severe psychological impact on an individual.

Objective: To provide evidence and consensus-based statements regarding the treatment of patients with AA in Korea.

Methods: We searched for relevant studies from inception to May 2021 regarding the systemic treatment of AA.