Publications by authors named "Jun-Zhao Cui"
Article Synopsis
- - The study analyzed somatic gene mutations and copy number variations (CNVs) in cerebrospinal fluid (CSF) ctDNA from 58 patients with neoplastic meningitis (NM) using next-generation sequencing and bioinformatics.
- - The most frequently mutated gene was TP53 (87.10%), with other notable mutations including EGFR (70.97%) and PTEN (62.90%), showing a predominance in the PI3K-Akt signaling pathway.
- - Findings suggest that these mutated genes could serve as potential biomarkers for diagnosing NM and might influence meningeal metastasis through specific signaling pathways.
Background: Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifestation, positive cerebrospinal fluid (CSF) cytology, and/or neuroimaging features. However, negative rate of CSF cytology and neuroimaging findings often result in a failure to diagnose MC from the patients who actually have the disease.
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