Publications by authors named "Julia W Angkeow"
Herpes simplex encephalitis (HSE) patients may develop secondary anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (NMDARE), associated with worsened long-term neurological outcome. Immunosuppressive treatment can limit NMDAR autoantibody-mediated pathology, but early predictive biomarkers for the risk of NMDARE are lacking. In a multicenter study, we performed unbiased antibody reactome profiling using Phage ImmunoPrecipitation Sequencing (PhIP-Seq).
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- Microbial exposures significantly affect healthspan by influencing the immune system and microbiota.
- A library of 95,601 peptide tiles covering 14,430 proteins with virulence factor annotations was created to analyze antibody responses using Phage ImmunoPrecipitation Sequencing (PhIP-Seq).
- The study observed the stability of antibody responses with age, identified specific associations with diseases like Crohn's and juvenile dermatomyositis, and demonstrated PhIP-Seq's effectiveness for large-scale health research.