Complex technology requires cultural innovations for distributing cognition.

Over the last decade, new research has shown how human collectives can develop technologies that no single individual could discover on their own. However, this research often overlooks how technology can become so complex that individuals cannot operate it on their own. At this level of technological complexity, distributing cognition is a necessary process for reducing cognitive load on individuals.

The construct validity of daily cognitive variability.

Cognition is a dynamic process and is subject to substantial variation across short and long timescales. It is becoming common to assess cognition repeatedly over short intervals to determine the correlates and consequences of such "cognitive variability." A high-frequency cognitive assessment approach is also an ideal method for measuring how cognition operates in daily life.

Disparities in clinical trial enrollment related to laser interstitial thermal therapy for central nervous system metastases.

Objective: Laser interstitial thermal therapy (LITT) is a minimally invasive option for the management of a variety of intracranial pathologies, including radiographically progressive tumor following stereotactic radiosurgery. Although LITT has been increasingly accepted in recent years, little is known regarding selection and outcomes for patients of diverse backgrounds, particularly at centers specializing in central nervous system (CNS) metastases.

Methods: Patients receiving their index LITT treatment for brain metastasis at a single center from 2015 to 2023 were retrospectively reviewed.

Chemogenetic activation of medial prefrontal cortex projections to the nucleus accumbens shell suppresses cocaine-primed reinstatement in EcoHIV infected mice.

HIV is highly comorbid with cocaine use disorder (CUD). Relapse is a major challenge in the treatment of CUD, and people living with HIV (PLWH) exhibit shorter time to relapse. One driver of relapse may be re-exposure to cocaine, which can be modeled in rodents using cocaine-primed reinstatement.

Behavioral variability as a function of people, situations, and their interaction.

Behavioral variability has long been a central topic in personality psychology. Traditionally, research has focused on differences in mean levels of behavior across situations and time, rather than taking a situation-specific approach to variability. These approaches neglect variability (or the opposite, consistency) within a situation, often treating within-situation variability as mere error.

EcoHIV infection effects on cocaine seeking and neuroimmune responses in male mice depend on cocaine exposure pattern.

Cocaine use disorders (CUDs) and human immunodeficiency virus (HIV) remain persistent public health dilemmas throughout the world. Cocaine seeking increases over a protracted period of abstinence, an effect known as the incubation of craving. Little is known about how HIV may modulate this process.

College student depressive symptoms linked to feeling worse during social media use and engaging in social media in more emotionally negative ways: An experimental approach.

Despite significant interest in how social media use (SMU) is associated with college student depression, little consensus has been drawn in this area. We argue that a critical step forward is examining how college student depressive symptoms are associated with (a) the emotions students experience while engaged in SMU and (b) how individuals choose to engage in weekly SMU in ways known to impact their emotions. Data were collected in 2022.

Predicting therapeutic clinical trial enrollment for adult patients with low- and high-grade glioma using supervised machine learning.

Therapeutic clinical trial enrollment does not match glioma incidence across demographics. Traditional statistical methods have identified independent predictors of trial enrollment; however, our understanding of the interactions between these factors remains limited. To test the interactive effects of demographic, socioeconomic, and oncologic variables on trial enrollment, we designed boosted neural networks (BNNs) for all glioma patients ( = 1042), women ( = 445, 42.

CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity.

The chemokine CXCL12 is a highly conserved peptide that regulates homeostatic processes in the brain throughout life. Recent work shows that CXCL12 increases dendritic spine density in cortical neurons, which requires activation of CXCL12's receptor CXCR4. This same pathway reverses cortical dendritic spine deficits and cognitive impairment in an animal model of neuroHIV.

Influence of sleep and cardiovascular health on cognitive trajectories in older adults.

Age-related changes in sleep have been associated with cognitive decline, yet causal pathways have not been identified. Evidence suggests reduced cardiovascular health may be a consequence of poor sleep and a precursor to cognitive decline. This observational cohort study used path analyses to determine whether cardiovascular disease risk mediated or moderated effects of sleep on yearly longitudinal change in cognition, estimated with linear growth models.

Towards a personalized happiness approach to capturing change in satisfaction.

Contemporary approaches examining the determinants of happiness have posited that happiness is determined bidirectionally by both top-down, global life satisfaction and bottom-up, domain satisfaction processes. We propose a personalized happiness perspective, suggesting that the determinants and consequences of happiness are idiographic (that is, specific) to each individual rather than assumed to be the same for all. We showed the utility of a personalized happiness approach by testing associations between life and domain satisfaction at both the population and personalized levels using nationally representative data of 40,074 German, British, Swiss, Dutch and Australian participants tracked for up to 33 years.

A systematic review of the patient reported outcome measures used to assess the impact of periodontitis and peri-implantitis on oral health related quality of life.

Introduction: Periodontal disease (PD) and peri-implantitis (PI) can have a significant impact on oral health related quality of life. It is important that any patient reported outcome measures accurately reflect this impact.

Aims: To identify the measures used to assess the impact of periodontal disease and peri-implantitis on oral health related quality of life.

Unclogging of the TOM complex under import stress.

Mitochondrial functions and biogenesis depend on the import of more than 1,000 proteins which are synthesized as precursor proteins on cytosolic ribosomes. Mitochondrial protein translocases sort the precursor proteins into the mitochondrial sub-compartments: outer and inner membrane, the intermembrane space and the matrix. The translocase of the outer mitochondrial membrane (TOM complex) constitutes the major import site for most of these precursor proteins.

Blocking the Dkk1-LRP6 interaction prevents acute amyloid-β-driven cognitive impairment.

Synapse loss driven by amyloid-β (Aβ) is an early event in Alzheimer's disease (AD). Although the mechanism by which Aβ drives synapse loss remain poorly understood data indicate that a disruption of Wnt signalling plays an important part. We have shown that Aβ exerts its effects on synapses through Dickkopf-1 (Dkk1), a secreted protein that acts upon Wnt signalling via a direct interaction with the canonical Wnt pathway co-receptor proteins, LRP5 and LRP6, preventing their interaction with the receptor Frizzled.

Chemogenetic Activation of Medial Prefrontal Cortex Projections to the Nucleus Accumbens Shell Suppresses Cocaine-Primed Reinstatement in EcoHIV Infected Mice.

HIV is highly comorbid with cocaine use disorder (CUD). Relapse is a major challenge in the treatment of CUD, and people living with HIV (PLWH) exhibit shorter time to relapse. One driver of relapse may be re-exposure to cocaine, which can be modeled in rodents using cocaine-primed reinstatement.

The impact of e-cigarette use on periodontal health: a systematic review and meta-analysis.

Background: Electronic Nicotine Delivery Systems (ENDS, e-cigarettes) are a popular alternative to traditional tobacco smoking.

Objective: To evaluate the effect of ENDS use on periodontal health.

Methods: A protocol was published in accordance with PRISMA standards.

Longitudinal Trajectories of Cognition and Neural Metrics as Predictors of Persistent Distressing Psychotic-Like Experiences Across Middle Childhood and Early Adolescence.

Objectives: Psychotic-like experiences (PLEs) may arise from genetic and environmental risk leading to worsening cognitive and neural metrics over time, which in turn lead to worsening PLEs. Persistence and distress are factors that distinguish more clinically significant PLEs. Analyses used three waves of unique longitudinal Adolescent Brain Cognitive Development Study data (ages 9-13) to test whether changes in cognition and structural neural metrics attenuate associations between genetic and environmental risk with persistent distressing PLEs.

Inter-chromosomal insertions at Xq27.1 associated with retinal dystrophy induce dysregulation of LINC00632 and CDR1as/ciRS-7.

In two unrelated families with X-linked inherited retinal dystrophy, identification of the causative variants was elusive. Interrogation of the next-generation sequencing (NGS) data revealed a "dark" intergenic region on Xq27.1 with poor coverage.

Comparison of failure rates between full-barium and striped barium distal shunt catheters: a matched case-control study.

Purpose: We hypothesize that distal shunt catheters fully impregnated with barium are more prone to failure compared to distal catheters with only a barium stripe. We sought to evaluate this distinction using a matched case-control study.

Methods: Patient records over an 8-year period were queried for distal shunt revisions for fracture or disconnection (cases).

Combination checkpoint blockade and laser interstitial thermal therapy in radiographically progressive non-small cell lung cancer brain metastases.

Background: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment being employed frequently for radiographically progressive brain metastases. Considerable interest exists in combining LITT-mediated in situ vaccination to license immune checkpoint blockade (ICB). No studies have examined the clinical feasibility of this combination in brain metastases.

Prenatal social disadvantage is associated with alterations in functional networks at birth.

Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development during a period of high neuroplasticity through hormonal, microbiome, epigenetic, and immune factors that cross the placenta and fetal blood-brain barrier. The current study examines prenatal social disadvantage to determine whether these exposures in utero are associated with alterations in functional brain networks as early as birth.

Role of Cardiovascular Risk in Associations of Brain-Derived Neurotrophic Factor with Longitudinal Brain and Cognitive Trajectories in Older Adults.

Background: Higher levels of brain-derived neurotrophic factor (BDNF) have been associated with better neurocognitive outcomes. BDNF is present in cardiovascular tissue, and some evidence suggests it may benefit cardiovascular function. The current study assessed whether there is a mediating and/or moderating role of cardiovascular health in the relationship between BDNF and brain and cognitive outcomes.

Psychosis Spectrum Symptoms Before and After Adolescent Cannabis Use Initiation.

Importance: Adolescent cannabis use has been consistently posited to contribute to the onset and progression of psychosis. However, alternative causal models may account for observed associations between cannabis use and psychosis risk, including shared vulnerability for both cannabis use and psychosis or efforts to self-medicate distress from psychosis spectrum symptomology.

Objective: To test 3 hypotheses that may explain cannabis-psychosis risk associations by modeling psychosis spectrum symptom trajectories prior to and after cannabis initiation across adolescent development (approximately 10-15 years of age).

A Diffusion Model Account of Cognitive Variability in Healthy Aging and Mild Cognitive Impairment.

Within-person variation in cognitive performance is linked to pathological aging. Cognitive fluctuations have not been analyzed using cognitive process models, such as the diffusion model, to characterize which cognitive processes contribute to variability in cognition. We collected 21 daily assessments of attention and personality in younger adults, healthy older adults, and those with mild cognitive impairment.