Publications by authors named "Joseph P Barchue"
Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure.
Am J Physiol Heart Circ Physiol
May 2021
Article Synopsis
- Heart failure (HF) is a complex condition affecting many individuals worldwide, and only about 50% of patients benefit from standard treatments, highlighting the need to explore its molecular differences.
- A study investigated epigenetic factors in end-stage HF patients, analyzing DNA methylation patterns in cardiac biopsies from men receiving left ventricular assist devices (LVAD), revealing distinct methylation signatures based largely on race.
- The findings suggest that African American patients have a higher mortality rate post-LVAD compared to Caucasian patients, possibly linked to socioeconomic disparities, indicating a need for further research into how these factors impact heart failure outcomes.
Ischemic cardiomyopathy (ICM) is the clinical endpoint of coronary heart disease and a leading cause of heart failure. Despite growing demands to develop personalized approaches to treat ICM, progress is limited by inadequate knowledge of its pathogenesis. Since epigenetics has been implicated in the development of other chronic diseases, the current study was designed to determine whether transcriptional and/or epigenetic changes are sufficient to distinguish ICM from other etiologies of heart failure.
View Article and Find Full Text PDFThe role of fibrinolytic genes and proteins in the development of allograft vascular disease.
J Heart Lung Transplant
August 2011
Background: We have previously shown that lack of plasminogen activator inhibitor-1 (PAI-1) expression in donor tissue greatly increases intimal proliferation (IP) after allogeneic transplantation. We sought to determine the relative role of PAI-1 and other fibrinolytic proteins in the development of IP.
Methods: We used an abdominal aortic transplant model in mice to investigate IP in 3 groups of 6 recipients.
Transforming growth factor-beta polymorphisms and cardiac allograft rejection.
J Heart Lung Transplant
October 2009
Background: Cytokine gene polymorphisms regulate cytokine expression. We analyzed transforming growth factor-beta (TGF-beta) allelic variation in codon 25 in susceptibility to acute rejection episodes in cardiac transplant recipients.
Methods: Between June 1997 and December 2001, 123 de novo heart transplants were performed at UAB with analysis based on 109 patients.