Publications by authors named "Jose Rivaldo De Lima"
New Insights into the Anticancer Effects and Toxicogenomic Safety of Two β-Lapachone Derivatives.
José Rivaldo De Lima
,
Alexandre José Da Silva Góes
,
Elizabeth Fernanda De Oliveira Borba
,
Meykson Alexandre da Silva
,
Rodrigo Ribeiro Alves Caiana
,
Mariza Severina De Lima Silva
Pharmaceuticals (Basel)
June 2025
β-Lapachone (β-lap) is an -naphthoquinone with potent antitumor activity. However, its clinical application is hindered by poor solubility and toxicity. Thiosemicarbazone derivatives of β-lap (BV3 and BV5) have demonstrated enhanced selectivity and anticancer efficacy in leukemia cells.
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