High-intensity ethanol binge drinking pattern in adolescence induces long-lasting impairment in the salivary glands and saliva quality of rats.

This study investigated the effects of high-intense ethanol consumption during abstinence periods on the biochemical and morphological profile of the salivary glands and saliva of rats. For this, 72 male rats, 35 days old, exposed to ethanol (20% w/v) in 4 cycles of binge drinking at a dose of 3 g/kg/day were used. The animals were evaluated 1 day after the last cycle, as well as 30 and 60 days of abstinence.

Impact of fluoride exposure at different concentrations on preosteoblastic cells: Molecular, biochemical, and morphological insights.

Fluoride can harm various tissues depending on its concentration and exposure duration. While its effects on mineralized tissues like bones and teeth are known, few studies have explored its impact on preosteoblastic cells. This study examined the effects of fluoride on differentiating osteoblastic cells.

Investigation of the effects of benznidazole on the salivary glands: A biochemical, morphological, and functional approach.

This study aimed to evaluate the possible biochemical effects of the administration of benznidazole on the parotid and submandibular salivary glands and saliva of rats, as well as on salivary components for the first time. Male Wistar rats (Rattus norvegicus), 66-days-old, weighing approximately 250 g were randomized into two groups: control, administered distilled water by gavage and benznidazole, administered benznidazole at a dose of 19.6 mg/kg daily by gavage over 15 days.

Evaluation of alveolar bone preservation and oxidative stress reduction with açai in Wistar rats with induced apical periodontitis.

Aim: This study aimed to investigate the effects of açai on bone and systemic damage caused by apical periodontitis (AP) in an animal model.

Methodology: In this experimental study, 32 male Wistar rats were randomly allocated into six groups-Control 14 days (n = 4), Control 28 days (n = 4), AP 14 days (n = 4), AP 28 days (n = 4), AP plus açai treatment for 14 days (n = 8) and AP plus açai treatment for 28 days (n = 8). Apical periodontitis was induced under general anaesthesia by exposing the pulp of the first molars to the oral environment.

High-intensity ethanol binge drinking accentuates bone damage in induced apical periodontitis in rats.

This study aimed to evaluate the effects of excessive and episodic consumption of ethanol (EtOH, a high-intensity drinking manner) on induced apical periodontitis in rats. Thirty-two animals were divided into the following four groups: control, EtOH, apical periodontitis, and EtOH + apical periodontitis. Ethanol exposure (3 g/kg 20 % w/v EtOH) was performed by orogastric gavage for 3 consecutive days, followed by 4 days of withdrawal for 4 weeks.

Physical training minimizes immunological dysfunction, oxidative stress and tissue destruction on experimental periodontitis in rats.

The objective of this study is to investigate the effects of a moderate intensity physical training protocol, on alveolar bone morphology of rats submitted to ligature-induced periodontitis. Twenty-eight male Wistar rats were divided into four groups, considering the presence/absence of periodontitis and presence/absence of training. The training protocol was performed on a treadmill, 30 min/day, 5 days a week, for 4 weeks.

Açai ( Mart.) supplementation promotes histological and ultrastructural changes in rats' alveolar bone.

The açai juice contains high concentrations of phenolic compounds, including cyanidin-3-glucoside and others flavonoids. The aim of this study was to evaluate the impact of açai supplementation on healthy mandibular alveolar bone in male albino rats of the Wistar strain. 24 rats were divided into 3 groups, in which one group received a daily dose of saline solution and the other two groups were treated with daily doses of clarified açai juice for 14 or 28 days.

Modulation of blood redox status by the progression of induced apical periodontitis in rats.

This study aimed to investigate if apical periodontitis in different periods changes systemic levels of the antioxidant and pro-oxidant parameters in Wistar rats. Twenty-four rats were randomly allocated into healthy animals, apical periodontitis at 14 days (AP14) and apical periodontitis at 28 days (AP28). The first mandibular molars were accessed in the AP groups, and the pulp chamber was exposed to the oral environment, inducing the apical lesion.

Fluoride Exposure and Salivary Glands: How Is Glandular Morphology Susceptible to Long-Term Exposure? A Preclinical Study.

Despite a strong body of evidence attesting to the effectiveness of fluoride (F) in preventing and controlling caries, some studies have sought to investigate the influence of F exposure on the salivary glands, organs that are essential for the maintenance of cavity homeostasis through salivary production, finding that exposure to F can cause biochemical and proteomic changes. Thus, this study aimed to investigate the morphological effects of prolonged exposure to F on the salivary glands of mice, at concentrations that would correspond to optimally fluoridated water (suitable for human consumption) and to fluorosis-endemic regions. Twenty-four male mice () were divided into three groups, according to F levels in the drinking water: 0 (control), 10, or 50 mg F/L, with an exposure period of 60 days.

Fluoride exposure duringintrauterine and lactation periods promotes changes in the offspring rats' alveolar bone.

The importance of fluoride (F) for oral health is well established in the literature. However, evidence suggests that excessive exposure to this mineral is associated with adverse effects at different life stages and may affect many biological systems, especially mineralized tissues. The purpose of this study was to investigate the effects of F exposure during pregnancy and breastfeeding on the alveolar bone of the offspring since the alveolar bone is one of the supporting components of the dental elements.