Publications by authors named "Jooyeon Suh"
Article Synopsis
- Periprosthetic tissue inflammation, often caused by wear debris from polyethylene in joint replacements, poses significant complications in surgeries.
- This study explored the impact of grafting a MEDSAH polymer onto polyethylene surfaces, finding that it reduced pro-inflammatory cytokine expression in mouse osteoblasts but did not affect macrophage inflammation.
- The results indicate that MEDSAH coatings could help reduce inflammation and prevent complications in joint replacements, but further clinical research and biomechanical studies are necessary to confirm their long-term effectiveness.
Decoupling NAD metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis.
Cell Rep Med
January 2024
Chondrosarcomas represent the second most common primary bone malignancy. Despite the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD) depletion, targeting the NAD synthesis pathway remains challenging due to broad implications in biological processes. Here, we establish SIRT1 as a central mediator reinforcing the dependency of chondrosarcoma cells on NAD metabolism via HIF-2α-mediated transcriptional reprogramming.
View Article and Find Full Text PDFSarcomas are rare and heterogeneous mesenchymal neoplasms originating from the bone or soft tissues, which pose significant treatment challenges. The current standard treatment for sarcomas consists of surgical resection, often combined with chemo- and radiotherapy; however, local recurrence and metastasis remain significant concerns. Although immunotherapy has demonstrated promise in improving long-term survival rates for certain cancers, sarcomas are generally considered to be relatively less immunogenic than other tumors, presenting substantial challenges for effective immunotherapy.
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