Publications by authors named "Joohyun An"
Type I interferons are essential for antiviral immunity but must be tightly regulated. The conserved transcriptional repressor SP140 inhibits interferon-β (Ifnb1) expression through an unknown mechanism. Here we report that SP140 does not directly repress Ifnb1 transcription.
View Article and Find Full Text PDFType I interferons (IFN-Is) are essential for antiviral immunity but must be tightly regulated. The conserved transcriptional repressor SP140 inhibits interferon beta () expression via an unknown mechanism. Here we report that SP140 does not directly repress transcription.
View Article and Find Full Text PDFBrain organoids are being recognized as valuable tools for drug evaluation in neurodegenerative diseases due to their similarity to the human brain's structure and function. However, a critical challenge is the lack of selective and sensitive electrochemical sensing platforms to detect the response of brain organoids, particularly changes in the neurotransmitter concentration upon drug treatment. This study introduces a 3D concave electrode patterned with a mesoporous Au nanodot for the detection of electrochemical signals of dopamine in response to drugs in brain organoids for the first time.
View Article and Find Full Text PDFHuman Motor System-Based Biohybrid Robot-On-a-Chip for Drug Evaluation of Neurodegenerative Disease.
Adv Sci (Weinh)
January 2024
Article Synopsis
- - Biohybrid robots are being developed for various applications but currently lack a central nervous system, limiting their use in neurodegenerative disease research.
- - A new biohybrid robot-on-a-chip model has been introduced that integrates a brain organoid, motor neuron spheroids, and muscle bundles to assess drug impacts on neurodegenerative diseases for the first time.
- - The model effectively measures the effect of levodopa on muscle movement, showing significant improvements in activity in a Parkinson's disease model, suggesting its potential as a standard for drug evaluation.
Article Synopsis
- Organic and inorganic materials in bioelectronics face issues like stiffness and low biocompatibility, prompting research into hydrogels that can better connect biological materials and electronics.
- Hydrogels offer flexibility and improved compatibility but struggle with low electrical conductivity and stability, which has led to the development of biohybrid hydrogels that incorporate nanomaterials to enhance performance.
- This review highlights recent studies on biohybrid hydrogels, detailing their components, applications in flexible/wearable devices, tissue engineering, and biorobotics, and aims to guide future developments in hydrogel bioelectronics.