Publications by authors named "Jonathan D Chick"
Front Psychiatry
January 2019
Article Synopsis
- Alcohol use disorder (AUD) is a serious brain disorder with high mortality and morbidity rates, and baclofen, a GABA-B receptor agonist, shows promise as a treatment option.
- The use of baclofen is controversial due to uncertainties in dosing, efficacy, and safety, with clinical trials showing varied results and maintenance doses ranging widely from 30 to over 300 mg/day.
- Baclofen may benefit patients with liver disease owing to its limited metabolism; however, its use is considered "off-label," and patients require close medical monitoring, especially at higher doses or with existing health issues.
