Acute kidney injury in patients with spontaneous intracerebral hemorrhage - Is it a real problem?

Introduction: Acute kidney injury (AKI) is common in critically ill intensive care unit patients, including those with intracerebral hemorrhage (ICH). Spontaneous ICH (sICH) accounts for 10-15% of all strokes and is a significant cause of death and disability in people over 40 years of age worldwide, and the development of AKI in these patients might further worsen their outcomes. The aim of the study was to determine the incidence and risk factors for AKI, as well as short-term outcomes in patients with sICH.

Factors Affecting Health-Related Quality of Life in Patients After a Liver Transplant: A Cross-Sectional, Single-Centre, Large-Cohort Study.

: Over the past decades there has been a remarkable improvement in the clinical outcomes and prognoses after orthotopic liver transplantation (OLTx). Health-related quality of life (HRQoL) has emerged as an important concept for assessing the success of this procedure. We aimed to assess critical aspects of HRQoL in patients transplanted at our centre.

Proenkephalin A 119-159 as an early biomarker of acute kidney injury in complex endovascular aortic repair: an explorative single-center cross-sectional study with the utilization of two measurement methods.

Background: Acute kidney injury (AKI) remains a significant complication following endovascular aneurysm repair (EVAR). Current diagnostic methods often detect kidney damage too late for effective intervention. This study evaluated proenkephalin A 119-159 as an early AKI biomarker after EVAR procedures, comparing point-of-care testing with the ELISA method.

Predicting long-term kidney graft failure using novel multi-omic blood-based biomarkers and artificial intelligence tools.

Kidney transplantation (KT) remains the preferred treatment for end-stage renal disease. With advancements in immunosuppressive regimens and KT surveillance, graft survival has improved, though mainly in short-term. Meanwhile, aging populations with multimorbidity and expanding donor criteria shape a new landscape for KT management.

Lipid-lowering agents in solid organ transplant recipients.

Although pre- and post-transplant dyslipidaemia is one of the most prevalent modifiable risk factors associated with an increased risk of major cardiovascular events, it remains underdiagnosed and undertreated. Moreover, the risk of cardiovascular events, acute allograft rejection and vasculopathy associated with dyslipidaemia is underestimated. Although the most prominent underlying cause of dyslipidaemia in solid organ transplant (SOT) recipients is immunosuppressants, their adjustment should be done with caution to avoid an acute graft rejection.

How to Promote the Idea of Transplantation-Second Life Social Campaign as an Example of Successful Action in Poland-What Youth Is Used to, Adults Remember.

: Solid organ transplantation, which began as an experimental procedure over 100 years ago, has now become a viable therapeutic option for the vast majority of patients with end-stage organ failure. However, a major limiting factor remains the shortage of organs available for transplantation. To expand the donor pool, it is essential to increase awareness of transplantation, including its legal, cultural, and ethical aspects.

Change in plasma electrolyte concentrations during hemodialysis following a controlled step-up in dialysate bicarbonate concentration.

Background: The concentration of bicarbonate in dialysis fluid (Dbic) that regulates acid-base balance in dialyzed patients is individually adjusted and may be modified during a hemodialysis session. We evaluated the impact of modifications of Dbic on plasma electrolytes.

Methods: Two midweek hemodialysis sessions were monitored in 25 anuric, prevalent hemodialysis patients (67.

Markers of Kidney Injury: Proenkephalin A and Uromodulin, but Not Dickkopf-3, Are Elevated in Patients After Hematopoietic Stem Cell Transplantation.

Kidney injury encompasses a broad spectrum of structural and functional abnormalities, directly associated with stem cell transplantation. Acute kidney injury and chronic kidney disease represent perilous complications of hematopoietic stem cell transplantation (HSCT), with an elevated risk of mortality and progression to end-stage renal disease. The early detection of these complications is, therefore, paramount, and research is increasingly focused on the identification of novel biomarkers of kidney damage.

Aligning kidney function assessment in patients with cancer to global practices in internal medicine.

Unlabelled: The kidney disease: Improving Global Outcomes (KDIGO) guideline recommends assessing kidney function using glomerular filtration rate (GFR) either through direct measurement or through estimation (eGFR) and describes a standardised classification of reduced kidney function. KDIGO guidelines have been adopted by most internal medicine specialities for the assessment and classification of kidney function, but not by cancer medicine. The development of the International Consensus Guideline on Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) aims to overcome the perceived challenges with KDIGO recommendations by describing their utility in patients with cancer.

Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice.

Unlabelled: Part 2 of the International Consensus Guideline on Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) offers drug-specific consensus recommendations based on both evidence and practical experience. These recommendations build upon the kidney function assessment and classification guidelines established in Part 1 of ADDIKD. Here we illustrate how dosing recommendations differ between ADDIKD and existing guidance for four commonly used drugs: methotrexate, cisplatin, carboplatin and nivolumab.

Proenkephalin (PENK): a functional biomarker in chronic kidney diseases - hope or just a new bystander?

Proenkephalin has recently emerged as a promising biomarker of kidney function which improves the early detection of acute kidney injury (AKI) compared to creatinine-based methods. Plasma Proenkephalin concentrations have shown a correlation with glomerular filtration rate (GFR) as assessed by gold standard methods. Previous studies have demonstrated its association with adverse clinical outcomes in various settings, including sepsis, heart failure, kidney transplantation, and chronic kidney disease (CKD).

Risk prediction of kidney function in long-term kidney transplant recipients.

Background: Limited tools exist for predicting kidney function in long-term kidney transplant recipients (KTRs). Elabela (ELA), apelin (APLN), and the APJ receptor constitute an axis that regulates vascular and cardiac physiology in opposition to the renin-angiotensin-aldosterone system.

Methods: Longitudinal, observational cohort of 102 KTRs who maintained graft function for at least 24 months, with no acute rejection history or active infection upon presentation.

Heart Failure-Focus on Kidney Replacement Therapy: Why, When, and How?

Heart failure (HF) is a major health problem because of its high prevalence, morbidity, mortality, and cost of care. An important contributor to morbidity and mortality in patients with advanced HF is kidney dysfunction. Almost half of HF patients develop cardiorenal syndrome (CRS).

ABCDE to identify and prevent chronic kidney disease: a call to action.

Kidney disease is a global health priority affecting >850 million people worldwide. This number is projected to increase over the coming decades given the increasing prevalence of diabetes, hypertension and obesity and the aging population. Chronic kidney disease (CKD) can reduce both life expectancy and quality of life and is intricately linked with cardiac and metabolic health-the cardiovascular-kidney-metabolic multimorbidity syndrome.

Nephrotoxicity in CAR-T Cell Therapy.

Chimeric antigen receptor (CAR)-T cell therapy is a novel therapy for the treatment of different hematologic malignancies. Besides its efficiency, CAR-T cell therapy is associated with significant toxicity, primarily manifested as cytokine release syndrome (CRS) and neurotoxicity. However, there are reports that CAR-T cell therapy is also nephrotoxic and this aspect has attracted less attention to date.

Cognitive impairment in kidney transplanted patients.

Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is an increased prevalence of cognitive impairment, and depression and other neurological complications, such as cerebrovascular disorders and movement disorders.

Chemotherapy-related cognitive impairment and kidney dysfunction.

Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cognition, leading to a phenomenon known as chemotherapy-related cognitive impairment (CRCI). This manifests as poor attention span, disturbed short-term memory, and general mental sluggishness.

Care pathways for patients with cognitive impairment and chronic kidney disease.

Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review the mutual consequences of CKD and CI on health outcomes and care pathways and highlight the complexities due to the involvement of different specialists. Our narrative review covers (i) the burden of CI among patients with CKD, (ii) the impact of CI on kidney health, (iii) access to kidney replacement therapy for people with CI, (iv) resources in cognitive care and (v) potential models for integrated 'nephro-cognitive' care.

Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD.

Chronic kidney disease (CKD) is commonly accompanied by cognitive dysfunction and dementia, which, in turn, increase the risk of hospitalization, cardiovascular events and death. Over the last 30 years, only four studies focused on genetic markers of cognitive impairment in CKD and kidney failure (KF), indicating a significant gap in research. These studies suggest potential genetic predispositions to cognitive decline in CKD patients but also underscore the necessity for more comprehensive studies.

The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms.

As the world's population continues to age, social patterns are changing, making aging a notable public health challenge. With aging as the major risk factor for cognitive decline, the global prevalence of dementia is projected to triple in the next 25 years. In light of the growing body of evidence of the involvement of microbiota in health and pathology, its role in age-related cognitive decline should be explored.

Bloodstream Infection in Oncologic Patient: First Report in Poland.

spp. () is a genus recognized as a new opportunistic human pathogen, causing systemic infections including premature neonates and adult patients. These fungi's natural resistance to caspofungin enables them to spread through vascular catheter colonization, making them a new etiological agent associated with fungal bloodstream infections (FBIs) and a significant contributor to high mortality rates.

Unravelling the Role of Serum Kallistatin on Cardiorenal Outcomes in Kidney Transplant Survivors.

Introduction: Kallistatin, a serine protease inhibitor, has been implicated in cardiovascular and renal protection. This study investigates its association with clinical characteristics and outcomes in long-term kidney transplant recipients (KTRs).

Methods: In this longitudinal observational cohort study, we enrolled 101 KTRs between September 2016 and October 2017.

Are there any session-to-session changes in ventilation during a weekly hemodialysis cycle?

Significant changes in pre-dialytic partial pressure of CO (pCO) during a week-long cycle of hemodialysis (HD) can be an effect of the intermittent supplementation of bicarbonate to correct chronic acidosis in patients. Mathematical modeling efforts carried out using the same parameters before each HD session might fail to produce accurate predictions of pCO and plasma bicarbonate concentration (C) because of this variability. A numerical model describing acid-base equilibrium changes during HD was applied to predict pCO, pH, and C in 24 chronic HD patients, using both fixed parameters for the whole week and estimating a new value of minute ventilation (V) and net acid generation rate (G) for each interdialytic interval.