Carbon Black CB-EDA Nanoparticles in Macrophages: Changes in the Oxidative Stress Pathway and in Apoptosis Signaling.

The influence of black carbon nanoparticles on J774.A1 murine cells was investigated with the objective of exploring the cytotoxicity of black carbon functionalized with ethylenediamine CB-EDA. The results showed that CB-EDA has a cytotoxic profile for J774.

Titanium Dioxide Nanoparticle (TiO NP) Induces Toxic Effects on LA-9 Mouse Fibroblast Cell Line.

Background/aims: Titanium dioxide nanoparticles (TiO NPs) are extensively applied in the industry due to their photocatalytic potential, low cost, and considerably low toxicity. However, new unrelated physicochemical properties and the wide use of nanoparticles brought concern about their toxic effects. Thereby, we evaluated the cytotoxicity of a TiO NP composed of anatase and functionalized with sodium carboxylate ligands in a murine fibroblast cell line (LA-9).

IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19.

Aim: COVID-19 pandemic has caused extensive burden on public life and health care worldwide. This study aimed to assess circulating levels of inflammatory cytokines in adult patients who were hospitalized with COVID-19 and stratified according to age (older or younger than 65 years) aiming to explore associations between these markers of inflammation and comorbidities.

Methods: This was a cross-sectional study of 142 COVID-19 patients consecutively admitted to the University Hospital of the Federal University of São Carlos, from July to October 2020.

Modulator Effect of Total Extract from the Endophytic RNC-D in and Macrophages.

Leishmaniases are diseases with high epidemiological relevance and wide geographical distribution. In Brazil, is related to the tegumentary form of leishmaniasis. The treatment for those diseases is problematic as the available drugs promote adverse effects in patients.

Robust Phenotypic Activation of Eosinophils during Experimental Infection.

Eosinophils are multifunctional cells that have cytotoxic proinflammatory activities and stimulate CD4 T-cells in experimental models of allergy and parasitic infections. Eosinophils, when exposed to antigens, are activated, expressing the CD38/CD69 molecules and exhibited increased expression of major histocompatibility complex (MHC-II), CD80 and CD86, suggesting they play a role upon antigen stimulation. In the present study, we evaluated the profile of eosinophils using conventional and image flow cytometry upon experimental infection.