Sensor-controlled digital game for Native American adults in the Lumbee Tribe with hypertension self-management: study protocol for a randomized controlled trial.

Background: Hypertension is a major risk factor for cardiovascular (CV) health in Native Americans (NAs), contributing to disparities in mortality, hospitalizations, and complications that include stroke and kidney diseases. However, despite the benefits of lifestyle modifications for CV health, systemic and cultural barriers hinder their adoption. To promote self-care behaviors, interventions must be culturally tailored and sustainable.

U.S. trust in physicians as key public health messengers during the H5N1 avian influenza outbreak.

The emerging threat of H5N1 avian influenza in humans has renewed the need for effective public health communication strategies, especially in light of reduced public trust in governmental institutions. During recent health crises, personal healthcare providers, particularly physicians, have emerged as the most trusted sources of information, surpassing institutions like the CDC and local health departments. This study explores the role of physicians as key messengers for health information related to H5N1 risk, vaccine guidance, and interventions among the U.

Bringing an immuno-PCR-based pharmacodynamic biomarker assay for reduced human IL-33 in serum, plasma, and aqueous humor into the clinic.

Immuno-polymerase chain reaction (iPCR) is an analytical technology that combines the specificity of antibody reagents with the sensitivity of polymerase chain reaction (PCR) signal amplification. Here we describe the optimization and qualification of an ultra-sensitive iPCR method designed to detect and quantify active (reduced form) interleukin-33 (IL-33) in human samples. The modified assay incorporates several improvements over a previous version utilized in research studies.

Long-Range Air Transportation for High-Consequence Infectious Diseases: Findings from a Global Tabletop Exercise on Patients with Viral Hemorrhagic Fever.

Objectives: Air medical services evacuation of patients with viral hemorrhagic fevers (VHFs) is a complex process. The United States National Emerging Special Pathogens Training and Education Center held an in-person tabletop exercise (TTX) in June 2023 to review and evaluate global processes and plans for long-range VHF air transportation capabilities. The TTX sought to test the coordination, prioritization, capacities, and plans for using VHF transportation capabilities when multiple countries simultaneously request support in air medical services evacuation of their sick or exposed citizens to a high-level isolation unit in their country for care.

Urban and Rural Perceptions of Potential H5N1 Vaccination and Dietary Changes in the United States.

Since 2021, the United States has experienced a significant increase in H5N1 ("avian flu") infections, spreading from wild fowl to domestic poultry, dairy cattle, and some humans, primarily agricultural workers. This study examines urban-rural differences in willingness to receive an H5N1 vaccine and change dietary behavior based on potential CDC recommendations. A survey (Aug 5-15, 2024) sampled 5,000 urban and 5,000 rural participants via online panels and live operator calls.

Attempted syntheses of ZnPhos-ruthenium complexes (ZnPhos = bis(2-diphenylphosphinophenyl)zinc).

Efforts to prepare Ru-ZnPhos complexes (ZnPhos = bis(2-diphenylphosphinophenyl)zinc) through reactions of the bis-cyclometallated phosphine RuZn complex [Ru(PPh)(CHPPh)(ZnMe)] (1) with the N-Et and N-Pr substituted N-heterocyclic carbenes IEtMe (1,3-diethyl-4,5-dimethylimidazol-2-ylidene) and IPrMe (1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene) gave instead the cycloruthenated/cyclozincated bimetallic species [Ru(IEtMe')(CHPPh)(PPh(CH)Zn{IEtMe})H] (5; IEtMe' = cyclometallated IEtMe) and [Ru(PPh)(CHPPh)(PPh(CH)Zn{IPrMe})H] (7) respectively, both of which feature new Zn-NHC bonds. An alternative approach involving substitution of free ZnPhos into ruthenium monodentate phosphine precursors proved marginally more successful. Heating [Ru(PPh)(CO)H] with excess ZnPhos gave a tetrametallic species 13 comprised of a Ru centre coordinated to ZnPhos and two ZnCHPPh ligands formed Zn-C cleavage of two ZnPhos ligands.

An unexpected bioanalytical challenge caused by positive control antibodies in a clinical immunogenicity assay - A simple solution and broadly applicable recommendations.

Anti-drug antibody (ADA) assays are an important element in the suite of bioanalytical methods required for assessment of the safety and efficacy of recombinant-protein therapeutics. As such, and following extensive optimization, there is an expectation that clinical ADA assays be fully validated for multiple performance parameters, including sensitivity, specificity, reagent stability, and robustness. Among critical reagents used in ADA assays, ADA positive controls (PCs) play a crucial role in multiple stages of assay development and validation, including selection of assay format, establishing assay cut-points, estimating assay relative sensitivity, assessing assay precision, as well as ensuring acceptable assay performance during sample testing.

ZnH as a Precursor to Catalytically Active Ru-ZnH Heterometallic Complexes.

Reaction of [Ru(IPr)(CO)H][BAr] (; IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene; BAr = B{3,5(CF)CH}) with an excess of ZnH in THF gives the structurally characterized neutral Ru(ZnH) complex [Ru(IPr)(CO)(ZnH)H] () and Ru(ZnH) salt [Ru(IPr)(CO)(ZnH)H][BAr] (). Crystallographic and computational analyses show the presence of both bridging Ru-H-Zn hydrides and terminal Ru-hydrides in the two products. Calculations also identify a low-energy H/ZnH exchange pathway that rationalizes the experimentally observed (EXSY) fluxionality of the hydrides in .

Association between in situ ventilation and human-generated aerosol exposure in meatpacking plants during the COVID-19 pandemic.

During the COVID-19 pandemic, meatpacking workers were disproportionately affected by disease. Large outbreaks at meatpacking facilities resulted in loss of life and threatened the well-being of workers across the globe. Much work was done throughout the pandemic to understand and prevent these outbreaks.

Enhancing Special Pathogen Preparedness Through Exercises: Navigating Dual Quarantine Activations.

This case study describes findings from an exercise conducted in April 2023 to assess the readiness of the National Quarantine Unit (NQU) and identify opportunities for improvement. The exercise is part of a multiyear effort to assess the readiness of quarantine and transport capabilities at the NQU through annual workshops, discussion-based exercises, and functional and full-scale exercises. The April 2023 exercise tested interagency coordination and decisionmaking, transport of individuals for monitoring, quarantine unit operations, and escalation of care for symptomatic individuals out of quarantine to high-level isolation units in the United States.

Hydridostannylene Derivatives of Magnesium and Calcium.

Reactions of a m-terphenylhydridostannylene with β-diketiminato magnesium and calcium hydrides provide bis-μ-hydrido species, the heterobimetallic constitutions of which are maintained after the addition of THF donor solvent. In both cases, reactions with hex-1-ene result in the formation of tetravalent organostannyl alkaline earth derivatives. Whereas the magnesium reagent undergoes facile twofold addition, the calcium-centered process is arrested after a single alkene reduction event.

Isolobal Cationic Iridium Dihydride and Dizinc Complexes: A Dual Role for the ZnR Ligand Enhances H Activation.

The reaction of [Ir(IPr)H][BAr] (; IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene; BAr = B{CH(3,5-CF)}) with ZnMe proceeds with CH elimination to give [Ir(IPr)(IPr')(ZnMe)H][BAr] (, where (IPr') is a cyclometalated IPr ligand). reacts with H to form tetrahydride [Ir(IPr)(ZnMe)H][BAr], , that loses H under forcing conditions to form [Ir(IPr)(ZnMe)H][BAr], . Crystallization of also results in the formation of its noncyclometalated isomer, [Ir(IPr)(ZnMe)][BAr], , in the solid state.

Developing Training in Response to High-Consequence Infectious Diseases and Preparedness Measures for the Future.

In recent history, outbreaks of high-consequence infectious diseases (HCIDs) have raised health security concerns among the global community. As HCIDs continue to emerge, public health systems around the world experience the burden of implementing adequate preparedness and response measures to ensure the safety and security of their populations. HCID outbreak response efforts have highlighted the need for specialized training in safety and infection prevention and control for frontline workers who may encounter ill patients.

High-Level Isolation: A Landscape Analysis of Global Capabilities and Opportunities to Advance the Field.

High-level isolation units (HLIUs) have been established by countries to provide safe and optimal medical care for patients with high-consequence infectious diseases. We aimed to identify global high-level isolation capabilities and determine gaps and priorities of global HLIUs, using a multiple method approach that included a systematic review of published and gray literature and a review of Joint External Evaluations and Global Health Security Index reports from 112 countries. A follow-up electronic survey was distributed to identified HLIUs.

Sustainability of an intervention for the prevention of substance use within Native American communities.

The outcomes of this study revealed the importance of recruiting local Native American tribal community members as participants in an Adult Facilitator Trainee Program for a cultural based intervention, Intertribal Talking Circle (ITC), that addresses prevention of substance use among Native American youth. Survey results indicate that Native-Reliance (cultural identity) and self-efficacy increased among the trainees from base-line to 3-months post the training session. Themes emerged from qualitative interviews conducted with the participants that described their readiness to implement and sustain the Talking Circle intervention program within their tribal communities after the research project was completed.

A commercial tobacco and alcohol use intervention for urban Native American youth.

Objective: Westernized alcohol and commercial tobacco use prevention approaches for Native Americans have not been effective, or sustainable. The overall objective of this study examined the effect of the culturally based Urban Talking Circle (UTC) intervention versus standard education (SE) program for the prevention of alcohol and commercial tobacco use among urban Native American youth.

Design: The study employed a 2-condition quasi-experimental design and utilized convenience and snowball sampling methods for recruiting 100 urban Native American youth participants in two urban Native American community program locations in Florida.

Mental health intervention development for indigenous youth: Essential elements and guiding principles.

There is a need for intervention studies to address mental health issues with Indigenous youth. The purpose of this work is to: 1) consider calming approaches introduced by Native-American adolescents who described in writing how they manage day-to-day stress; and 2) identify culturally relevant constructs (elements and principles) for development of mental health promotion interventions for use with Indigenous youth. Central ideas shared by Native-American adolescents were merged with existing literature to identify essential elements and guiding principles for intervention development.

A pilot study of virtual Harm Reduction Talking Circles for American Indian and Alaska Native adults with alcohol use disorder.

Prior research suggests that culturally aligned, accessible and lower-barrier interventions are well-placed to align with the needs of American Indian and Alaska Native (AI/AN) people with alcohol use disorder (AUD). Taking into account community members' suggestions and the need for physical distancing during the COVID-19 pandemic, our team developed a protocol for virtual Harm Reduction Talking Circles (HaRTC) to incorporate these points. The aims of this 8-week, single-arm pilot were to initially document feasibility, acceptability, and outcomes associated with attendance at virtual HaRTC, which integrates the accessibility of virtual connection, a lower-barrier harm-reduction approach, and a culturally aligned intervention.

Heteroallene Insertions into Tin(II) Alkoxide Bonds.

A series of iso-carbamate complexes have been synthesized by the reaction of [Sn(OPr)] or [Sn(OBu)] with either aryl or alkyl isocyanates, ONC-R (R = 2,4,6-trimethylphenyl (Mes), 2,6-diisopropylphenyl (Dipp), isopropyl (Pr), cyclohexyl (Cy) and -butyl (Bu)). In the case of aryl isocyanates, mono-insertion occurs to form structurally characterized complexes [Sn{κ--R-NC(OPr)O}(μ-OPr)] (: R = Mes, : R = Dipp) and [Sn{κ--R-NC(OBu)O}(μ-OBu)] (: R = Mes, : R = Dipp). The complicated solution-state chemistry of these species has been explored using H DOSY experiments.