Publications by authors named "Johanna Christine Jansing"
Article Synopsis
- Bronchopulmonary dysplasia (BPD) is a serious lung condition commonly seen in premature babies, and this study focused on creating a hyperoxia-based model of BPD using preterm rabbits to analyze lung changes.
- Researchers observed that after seven days of hyperoxia exposure, the rabbits showed significant reductions in lung function, including decreased inspiratory capacity and increased lung resistance, alongside indications of pulmonary hypertension.
- Stereological analysis revealed that hyperoxic rabbits had fewer alveoli and reduced alveolar surface area, along with thickened alveolar walls and fluid buildup, mirroring the lung damage seen in human BPD.
Acute lung injury (ALI) is characterized by enhanced permeability of the air-blood barrier, pulmonary edema, and hypoxemia. MicroRNA-21 (miR-21) was shown to be involved in pulmonary remodeling and the pathology of ALI, and we hypothesized that miR-21 knock-out (KO) reduces injury and remodeling in ALI. ALI was induced in miR-21 KO and C57BL/6N (wildtype, WT) mice by an intranasal administration of 75 µg lipopolysaccharide (LPS) in saline ( = 10 per group).
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