Publications by authors named "Joanna Stojak"
Article Synopsis
- The CRISPR/Cas9 technique is being used to improve cattle health and welfare by modifying their genomes effectively.
- Researchers developed a quick and efficient cloning-free protocol for creating large genetic deletions in MDBK cell lines, which are commonly used in studies.
- Key features of this protocol include pre-screening sgRNA efficiency, reliable genomic edit detection through PCR and DNA sequencing, and single cell sorting for detailed genetic information.
Article Synopsis
- Population genetic screening for cancer has sparked debates over costs and ethical concerns, with varying standards across countries focusing primarily on those with a personal or family cancer history.
- In a study involving 1076 Polish individuals, a broad analysis of genetic variants uncovered 19,551 rare variants in genes linked to cancer, with a notably low frequency of pathogenic variants like those in BRCA1/BRCA2.
- The study highlights challenges in accurately assessing the pathogenicity of rare variants and suggests the need for further research to improve understanding of variant frequency and implications for population-based whole genome screening.
The vertebrate photoperiodic neuroendocrine system uses the photoperiod as a proxy to time the annual rhythms in reproduction. The thyrotropin receptor (TSHR) is a key protein in the mammalian seasonal reproduction pathway. Its abundance and function can tune sensitivity to the photoperiod.
View Article and Find Full Text PDFUndoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified 18,191 significant SNPs for severe and 11,799 SNPs for resistant phenotype, showing that a great number of loci were significant in different COVID-19 representations.
View Article and Find Full Text PDFSevere outcomes of COVID-19 account for up to 15% of all cases. The study aims to check if any gene variants related to cardiovascular (CVD) and pulmonary diseases (PD) are correlated with a severe outcome of COVID-19 in a Polish cohort of COVID-19 patients. In this study, a subset of 747 samples from unrelated individuals collected across Poland in 2020 and 2021 was used and whole-genome sequencing was performed.
View Article and Find Full Text PDFCOVID-19 infections pose a serious global health concern so it is crucial to identify the biomarkers for the susceptibility to and resistance against this disease that could help in a rapid risk assessment and reliable decisions being made on patients' treatment and their potential hospitalisation. Several studies investigated the factors associated with severe COVID-19 outcomes that can be either environmental, population based, or genetic. It was demonstrated that the genetics of the host plays an important role in the various immune responses and, therefore, there are different clinical presentations of COVID-19 infection.
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- Carnivores like the red fox show weak genetic structure across large areas, complicating the tracking of their post-glacial movement patterns.
- This study utilized genome-wide data from 524 red foxes to explore variations and genetic mixing across European populations, revealing important refugial areas and endemism, particularly in Spain.
- The research also tested various recolonization scenarios post-Last Glacial Maximum, concluding that natural colonization of Ireland was more plausible than human introduction, suggesting a richer mammalian community on the island during the early post-glacial era.
Hantavirus infections in humans in Poland-current state of knowledge and perspectives for research.
Eur J Public Health
October 2020
Background: In Europe, hantaviruses cause serious human disease, hemorrhagic fever with renal syndrome (HFRS). The geographic distribution of human cases of HFRS is a consequence of distribution of reservoir host species. Epidemiology of HFRS is well-studied in Western Europe, while data from Central and Eastern Europe are poor or unavailable.
View Article and Find Full Text PDFThe common vole (Microtus arvalis) has been a model species of small mammal for studying end-glacial colonization history. In the present study we expanded the sampling from central and eastern Europe, analyzing contemporary genetic structure to identify the role of a potential 'northern glacial refugium', i.e.
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