Are high-' polymorphs metastable? Insight from pharmaceutical polymorphs.

High-' polymorphs are hypothesized to be kinetically trapped products and hence less stable than their low-' counterparts (' = number of symmetry-independent molecules in a crystal structure). Although the existence of such a symmetry-stability relationship would be of fundamental importance to the structural chemistry of molecular crystals, it has yet to be supported by experimental or computational evidence. A major challenge in analyzing high-' crystal structures is the large number of atoms, which makes accurate quantum chemical evaluation of their lattice cohesive energies (LCEs) computationally intensive.

Unravelling the potential of plasma DNA methylation in the detection and surveillance of esophageal cancer.

Esophageal cancer (EC) continues to pose a significant clinical challenge due to the absence of a reliable early detection method, leading to late-stage diagnoses and poor patient outcomes. The recent study by Liu presents a promising breakthrough, demonstrating that plasma DNA methylation markers-SHOX2, SEPTIN9, EPO, and RNF180-offer a non-invasive approach for early EC detection with 76.19% sensitivity and 86.

The Outcome of Arthroscopic Anterior Cruciate Ligament Reconstruction in Low-Demand, Non-athletic Patients Following a Home-Based Rehabilitation Protocol.

Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction is a common orthopedic procedure. Most of the literature is on high-demand athletic patients, with little information about the outcomes of low-demand patients. Therefore, we aim to assess the outcomes of non-athletic patients following home-based rehabilitation.

Outcome of Scaphoid Nonunion Using Open Reduction and Internal Fixation With Iliac Crest Bone Graft (Fisk-Fernandez Technique).

Introduction The scaphoid is the most common carpal bone to be fractured and has a high propensity for nonunion. Restoration of scaphoid length mitigates the chances of long-term complications. The aim of this study was to assess the functional outcome of the Fisk-Fernandez technique for the treatment of scaphoid nonunion by using open reduction and internal fixation with trapezoidal iliac crest bone graft.