Automatic segmentation of clear cell renal cell carcinoma based on deep learning and a preliminary exploration of the tumor microenvironment.

Background: Whole-slide imaging (WSI) is increasingly becoming a standard method for diagnosing clear cell renal cell carcinoma (ccRCC). This advanced imaging technique allows for high-resolution examination of tissue sections, improving diagnosis and management of renal cancers. Immunotherapy has emerged as an effective treatment for tumors; however, the differential characteristics of the tumor microenvironment (TME) significantly influence therapeutic outcomes.

Insights Into Proliferation Effects of Low-Dose Glyphosate on Phytoplankton Communities.

Glyphosate-based herbicides are among the most widely used agricultural chemicals globally, and their widespread application presents risks to environmental health and aquatic ecosystems. Continuous glyphosate inputs disrupt phytoplankton communities, potentially triggering harmful algal blooms. This study examines the proliferation of microalgal species exposed to low glyphosate concentrations (0.

MsTGANet: Automatic Drusen Segmentation From Retinal OCT Images.

Drusen is considered as the landmark for diagnosis of AMD and important risk factor for the development of AMD. Therefore, accurate segmentation of drusen in retinal OCT images is crucial for early diagnosis of AMD. However, drusen segmentation in retinal OCT images is still very challenging due to the large variations in size and shape of drusen, blurred boundaries, and speckle noise interference.

Early Stage Impacts of Adenoidectomy With/Without Tonsillectomy on Immune Functions of Children Aged Less Than Three Years.

To evaluate the early stage effects of adenoidectomy with/without tonsillectomy on immune functions in children aged <3 years. Twenty-four children aged <3 years underwent adenoidectomy with/without tonsillectomy were included. The levels of IgG, IgA, IgM, C3, and C4 were measured for humoral immunity, and the levels of CD3, CD4, CD8, CD19, CD56, CD3CD4CD8, and CD3CD4CD8 T cells were measured for cellular immunity before and 2 weeks after the operation.

Improved cGAN based linear lesion segmentation in high myopia ICGA images.

The increasing prevalence of myopia has attracted global attention recently. Linear lesions including lacquer cracks and myopic stretch lines are the main signs in high myopia retinas, and can be revealed by indocyanine green angiography (ICGA). Automatic linear lesion segmentation in ICGA images can help doctors diagnose and analyze high myopia quantitatively.

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age: A cohort study.

To investigate the short- and long-term impacts of adenoidectomy with/without tonsillectomy on the immune functions of young children < 3 years of age.This longitudinal prospective study included 40 pediatric patients (age <3 y) undergoing adenoidectomy with/without tonsillectomy for snoring and sleep apnea. Serum immunoglobulin IgA, IgG, IgM, complement C3, and C4 levels were measured for the status of humoral immunity; CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were measured for the status of cellular immunity.

Preparation of gemini surfactant/graphene oxide composites and their superior performance for Congo red adsorption.

Gemini surfactant/GO composites (10-2-10/GO, 12-2-12/GO, and 14-2-14/GO) have been successfully prepared using three gemini surfactants with different tail chain lengths. The morphology and physicochemical properties of the as-synthesized composites were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform-infrared spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The gemini surfactant/GO composites were applied to the adsorption of Congo red dye, and from the experimental data, optimum adsorption conditions, adsorption kinetics, and isotherms were obtained.

Correlation between BRAF mutation and clinicopathological features in pediatric papillary thyroid carcinoma.

In adults, the presence of the BRAF mutation in papillary thyroid cancer (PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF mutation in 48 pediatric patients with PTC, aged 3-13 years.

[Distribution and drug resistance of the pathogenic bacteria from sputum specimens of 1 125 children with tracheo bronchial foreign bodies].

Objective: To analyze the distribution and drug susceptibility of the pathogenic bacteria in the airway secretions in children with tracheobronchial foreign bodies so as to assist physicians in clinical prescription.

Methods: Sputum specimens of 1 125 children with tracheobronchial foreign bodies were collected in removal of the foreign bodies by rigid bronchoscope, and the drug susceptibility test was performed.

Results: Pathogenic bacteria were detected in 218 (19.

[Cloning and expression of Tssk1 & Tssk2 in mice and the presence & localization of them in mature sperm].

We sought to experimentally verify if testis specific serine/threonine kinases (Tssks) play a role in spermatogenesis and/or the regulation of sperm function. Purified Tssk proteins were obtained based on cloning and expression of mouse Tssk1 and Tssk2. Tssk1 and Tssk2 were detected in mature mouse and human sperm by western blotting.

[A clinical study of the acoustic rhinometry in nasal and nasopharyngeal airway of children with adenoid vegetation].

Objective: To investigate the significance of the AR measurement in diagnosis of adenoid vegetation and evaluation of the efficiency of adenoidectomy.

Method: Twenty-three healthy children and 27 children with adenoid vegetation were studied by ECCOVISION acoustic rhinometry (AR).

Results: Tthe NAR of the in-patients before adenoidectomy [(0.

[Structural characteristics of infrared spectra for polyaluminum chloride in enhanced reactions of modification].

As an important preparation method of Inorganic Polymer Flocculants (IPFs) with all-round performance, the use of enhanced reactions of modification for Polyaluminum Chlorides (PAC) is a trend of application. In this paper, auctorial-made multicore oligomers as a complexing agent, polysilicate as a crosslinking agent and polyacrylamide as a compounding agent are respectively used to enhance PAC and prepared three kinds of IPFs, named CO-PAC, CR-PAC and PAM-PAC. The Fourier Transform Infrared spectra (FTIR) of the three flocculants show that there have been found new chemical bonds beyond Al-OH in their structures, and each characteristic band of primary group in PAC has a band shift to a lower frequency due to its structural aberration.