Efficient and Protective Upgrading of Uncondensed Lignin Extraction with High Yield and High Purity: Mechanistic Insights into Lewis Acid Catalysis Coupled with PEG Stabilization.

Maximizing the extraction and valorization of highly reactive lignin from lignocellulosic biomass is crucial for lignin-first biorefining. However, achieving high yield, superior purity, and structural preservation simultaneously is challenging. Herein, we developed a Lewis acid-catalyzed deep eutectic solvent (DES) system employing ferric chloride (FeCl) coordinated with polyethylene glycol (PEG) to selectively extract structurally intact lignin.

Clinical characteristics analysis of pediatric spinal cord injury without radiological abnormality in China: a retrospective study.

Purpose: This study aims to analyze the clinical characteristics of Chinese children with spinal cord injury (SCI) without radiographic abnormality (SCIWORA) and explore their contributing factors and mechanisms of occurrence.

Methods: A retrospective analysis was conducted on the clinical data of pediatric patients diagnosed with SCIWORA from January 2005 to May 2020. Epidemiological, etiological, mechanistic, therapeutic, and outcome aspects were analyzed.

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.

Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression and metastasis of osteosarcoma, CEMIP was found to be overexpressed in osteosarcoma tissues when compared to adjacent non-tumor tissues, and its expression was positively associated with a poor prognosis in osteosarcoma patients.

Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGFβ) superfamily of secreted molecules. BMPs play essential roles in multiple developmental and homeostatic processes in metazoans. Malfunction of the BMP pathway can cause a variety of diseases in humans, including cancer, skeletal disorders and cardiovascular diseases.