Effects of Process Parameters on Defect Formation in Laser Additive Manufacturing of a Novel Ni-Based Superalloy.

Laser additive manufacturing offers significant advantages for fabricating and repairing complex components. However, the complex solidification and remelting processes in nickel-based superalloys for additive manufacturing can introduce defects such as voids and cracks. Therefore, process parameters are crucial, as they significantly impact solidification and remelting, thereby affecting defect formation.

Effects of chemical and physical deimmunogenicity methods on the biological and biomechanical properties of allogeneic tendons.

To compare the differences in biological and biomechanical characteristics of cadaver tendon treated by deep freezing, 95wt.% ethanol, tributyl phosphate (TBP), and sodium dodecyl sulfate (SDS) respectively. A total of 50 fresh tendon specimens were randomly divided into five groups, and four groups were treated with deep freezing (- 80 °C), 95wt.

Genotype and phenotype correlation in von Hippel-Lindau disease based on alteration of the HIF-α binding site in VHL protein.

Purpose: Von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that reduces life expectancy. We aimed to construct a more valuable genotype-phenotype correlation based on alterations in VHL protein (pVHL).

Methods: VHL patients (n = 339) were recruited and grouped based on mutation types: HIF-α binding site missense (HM) mutations, non-HIF-α binding site missense (nHM) mutations, and truncating (TR) mutations.

Risk factors for survival in patients with von Hippel-Lindau disease.

Background: Historically, von Hippel-Lindau (VHL) disease is characterised by a poor survival. Although genotype-phenotype correlation has been described in many studies, the risk factors for VHL survival remain unclear. This study aims to evaluate the median survival of Chinese patients with VHL disease and explore whether VHL survival is influenced by genetic and clinical factors.