Publications by authors named "Jin-Chao Xing"
Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic orthoflavivirus causing human encephalitis and reproductive disorders in pigs. Cell-intrinsic antiviral restriction factors are the first line of defense that prevent a virus from establishing a productive infection, while the molecular mechanism of the virus-host interaction is still not fully understood. Our in vitro experiments demonstrated that the Solute Carrier Family 25 Member 12 (SLC25A12) interacted with the JEV nonstructural protein 1 (NS1) and inhibited JEV replication.
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- - Japanese encephalitis virus (JEV) significantly affects both livestock and human health, but the specific host factors involved in its lifecycle are not well understood.
- - Researchers used a large CRISPR/Cas9 screen targeting over 19,000 human genes to identify 11 essential genes for JEV replication, including PRLHR and ASCC3.
- - The study revealed that knocking down PRLHR disrupted autophagic flux, ultimately inhibiting JEV infection, providing valuable insights for future antiviral drug development.