Publications by authors named "Jihyun Youm"
Article Synopsis
- The COVID-19 pandemic has highlighted the need for effective therapeutic interventions alongside vaccines, especially given the rapid mutation of the SARS-CoV-2 virus.
- This study investigates the antiviral properties and safety of 6'-Hydroxy justicidin B (6'-HJB), a compound from traditional Chinese medicine, as a potential treatment for COVID-19.
- Results show that 6'-HJB effectively inhibits SARS-CoV-2 growth with lower toxicity than remdesivir and has a favorable safety profile in both cell lines and ferrets, indicating it may be a promising therapeutic option.
Importance: Endochondral ossification plays an important role in skeletal development. Recent studies have suggested a link between increased intracellular reactive oxygen species (ROS) and skeletal disorders. Moreover, previous studies have revealed that increasing the levels of myeloperoxidase (MPO) and osteopontin (OPN) while inhibiting NADPH oxidase 4 (NOX4) can enhance bone growth.
View Article and Find Full Text PDFThe bromodomain and extraterminal domain (BET) family proteins recognize acetyl-lysine (K) at the histone tail through two tandem bromodomains, i.e., BD1 and BD2, to regulate gene expression.
View Article and Find Full Text PDFOur previous study revealed that the ethanolic extract of Justicia procumbens ameliorates ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of asthma. However, the mechanism of action of the extract remains unknown. In this study, we prepared DW2008S, an optimized and standardized powder extracted from J.
View Article and Find Full Text PDFArticle Synopsis
- DW2008 is an anhydrous ethanol extract from the plant Justicia procumbens developed by Dong-Wha Pharmaceutical as a possible treatment for asthma.
- The study demonstrated that DW2008 effectively reduced inflammation in a mouse asthma model by lowering specific inflammatory cells and Th2 cytokines compared to other extracts.
- Major components justicidin A and B in DW2008 showed strong effects in decreasing Th2 cytokine levels and provided significant protection against airway inflammation, indicating DW2008's promise as an anti-asthmatic drug.