Publications by authors named "Jiang-Bin Chen"
Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial.
Signal Transduct Target Ther
September 2021
Article Synopsis
- A study involving 920 patients with stable angina tested the efficacy of Danhong injection (DHI), a polypharmacological drug, over 14 days, finding that DHI significantly improved patient-reported angina frequency compared to a placebo.
- There were no significant differences in major vascular events or serious side effects between the DHI and placebo groups, indicating DHI's safety in this population.
- RNA sequencing identified a new therapeutic module related to blood coagulation and cholesterol metabolism as a potential target for DHI's effects, highlighting a connection between this module and positive changes in angina symptoms.
Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation.
Biomedicines
April 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored. The current study found that sanguinarine had an inhibitory effect on thrombus formation.
View Article and Find Full Text PDFRhoA/ROCK pathway regulates hypoxia-induced myocardial cell apoptosis.
Asian Pac J Trop Med
November 2014
Objective: To observe the regulatory effects of RhoA/ROCK pathway on the apoptosis of cardiac myocyte induced by anoxia and its mechanism.
Methods: The model of cardiac myocyte anoxia was established. The beat pulsations and apoptosis rates after 1 h, 3 h, 6 h, 9 h and 12 h of anoxia were recorded and the expressions of RhoA, ROCK1/2, p-PI3K, p-AKT and caspae-3 were detected, too.
[Effects of ventricular arrhythmia during early ischemic myocardium with captopril].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
February 2006