Publications by authors named "Jian-Pei Huang"

Background: Pregnant women are vulnerable to climate change, with high ambient temperature (AT) associated with adverse birth outcomes. Inconsistent study designs, limited metrics, and unclear roles of greenness as an adaptation strategy hinder region-specific climate policies. This study assessed the effects of prenatal heat exposure on birth outcomes and whether greenness moderates this association.

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  • A rare case of trisomy 18 of maternal origin was presented involving a 38-year-old woman whose pregnancy had multiple serious fetal abnormalities, including omphalocele and ectopia cordis.
  • Prenatal ultrasounds at 12 weeks revealed severe defects such as anencephaly and spine deformities, leading to the termination of the pregnancy in the 13th week.
  • Genetic testing confirmed a karyotype of 47, XX + 18, indicating that the extra chromosome came from the mother, which can guide genetic counseling for future pregnancies.
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  • The study discusses the prenatal diagnosis of Jacobsen syndrome in a 41-year-old pregnant woman, which was linked to specific chromosomal abnormalities detected through advanced genetic testing.
  • The fetus exhibited multiple congenital anomalies including growth restrictions, heart defects, and physical deformities, prompting amniocentesis for further analysis.
  • Chromosome microarray analysis (CMA) revealed significant deletions and duplications in chromosomes 11 and 8, respectively, confirming the diagnosis and illustrating the effectiveness of CMA in identifying complex genetic issues in prenatal cases.
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  • - A 30-year-old woman underwent prenatal ultrasound at 14 weeks and was found to be carrying a fetus with multiple congenital anomalies, prompting chromosome microarray analysis (CMA) after the pregnancy was terminated.
  • - The analysis revealed a significant deletion on chromosome 5 (5q14.3-q31.1), affecting numerous genes, including NR2F1 and MEF2C, indicating a genetic basis for the fetal conditions observed.
  • - CMA proves to be an effective tool in identifying genetic abnormalities in fetuses with unexplained congenital anomalies, highlighting its value in prenatal genetic testing.
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  • The study explores the impact of a mobile health (mHealth) intervention on overweight and obese pregnant women, focusing on weight management from pregnancy through six months postpartum.
  • Results show that women in the intervention group had lower body weight before childbirth and maintained similar weight postpartum compared to the control group, but the effect on weight retention after six months was minimal.
  • Additionally, newborns from the mHealth intervention group had significantly lower birth weights, suggesting the intervention is effective in managing excessive weight gain during pregnancy, especially for those with obesity.
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  • Hair cortisol concentration (HCC) in kids can show how stressed they are, and this study looked at kids aged 6 months to 4 years.
  • Researchers found that a child's HCC is linked to their parents' HCC levels, especially if the moms are feeling anxious or sad.
  • The study suggests that checking HCC in hair can help identify stress in young kids and allow for help before it gets worse.
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Background: In recent years, smart devices have become an integral part of daily life. However, longitudinal studies, particularly those regarding the relationship between toddlers' smart device usage and behavioral outcomes, are limited. Understanding the impact of parent-child interactions on this relationship is crucial for enhancing toddlers' developmental outcomes.

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Objective: We present perinatal imaging findings of a fetus with Pfeiffer syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2 presenting a cloverleaf skull, craniosynostosis and short limbs on prenatal ultrasound mimicking thanatophoric dysplasia type II (TD2).

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Objective: Maternal body mass index (BMI) and gestational weight gain (GWG) are believed to be associated with fetal conditions and maternal complications. The aim of this study was investigating the influence of maternal prepregnancy BMI and GWG on pregnancy outcomes and exploring the optimal GWG in Taiwanese singleton women.

Materials And Methods: Retrospective records of 8146 singleton pregnant women between 2017 and 2019, obtained from a tertiary center in Taiwan were reviewed, and the associations between maternal prepregnancy BMI, GWG, and perinatal outcomes were analyzed.

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Background: Although miscarriage and termination of pregnancy affect maternal mental illnesses on subsequent pregnancies, their effects on the positive mental health (e.g., eudaimonia) of both first-time and multi-time parents have received minimal attention, especially for fathers.

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The programming of innate and adaptive immunity plays a pivotal role in determining the course of pregnancy, leading to either normal term birth (TB) or preterm birth (PB) through the modulation of macrophage (M1/M2) differentiation. Extracellular vesicles (EVs) in maternal blood, harboring a repertoire of physiological and pathological messengers, are integral players in pregnancy outcomes. It is unknown whether urinary EVs (UEVs) could serve as a non-invasive mechanistic biomarker for predicting PB.

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Introduction: Although mobile devices are used ubiquitously, studies on their detrimental effects on preschoolers are limited. Furthermore, no study has considered shared reading and mobile device usage simultaneously. Therefore, this study examined the effects of mobile devices and shared reading on preschoolers' development along with the effects of maternal depression on this association.

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Background: Women usually decrease their physical activity (PA) after becoming pregnant. The change in PA may influence their symptom distress (SD). The changes and correlations between SD and PA throughout pregnancy remain unclear.

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Iron deficiency anemia (IDA) is a major health burden among women in Asia. Key issues in IDA management in Asia are under-diagnosis and under-treatment. The lack of Asia-specific guidelines, and suboptimal utilization of treatment compounds the management of IDA.

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Background: Although studies have reported the effects of inadequate sleep on maternal health, few have examined the relationships of maternal sleep patterns with fetal health and early childhood development. This study investigated maternal sleep duration patterns from early pregnancy to 3-years postpartum and their effects on birth outcomes and child development.

Methods: This study recruited pregnant women and their partners during prenatal visits at five selected hospitals in the Taipei area; follow-up lasted from July 2011 to April 2021.

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Background: The level of vitamin D in pregnant women and the effect of vitamin D supplementation are lack in Taiwan.

Objective: To investigate the vitamin D serum level and the effect of its supplementation on pregnancy.

Methods: We included 1048 pregnant women who underwent prenatal exam with known serum 25-hydroxyvitamin D3 [25(OH)D3] levels and delivery at the Mackay Memorial Hospital, Taipei, Taiwan during 2015-2018.

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Objectives: To understand and describe overweight and obese pregnant women's mHealth app experiences in managing gestational weight gain (GWG) for optimal weight goals.

Design: A focus group study.

Setting: We identified and invited pregnant women from a prenatal outpatient clinic in a metropolitan city in Northern Taiwan.

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Background: Although maternal mental illnesses have been found to influence child health and development, little is known about the impact of maternal positive well-being on child health and development. Therefore, this longitudinal study investigated the effects of prenatal subjective well-being on birth outcomes and child development by considering the potential modifier effect of parity.

Methods: Pregnant women in early stages of pregnancy were recruited at five selected hospitals in Taipei, Taiwan, during their prenatal appointments since 2011.

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Objective: To explore the effectiveness of a nurse-led mobile health (mHealth) intervention to prevent excessive gestational weight gain (GWG) in overweight and obese women.

Methods: A randomized controlled trial with an experimental study design. Ninety-two pregnant women with body mass index (BMI) ≥25 kg/m at less than 17 weeks gestation were recruited from two prenatal clinics in northern Taiwan from January to June 2020.

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Aim: The percentage of medicine graduates opting for residency in obstetrics and gynecology (OB/GYN) has been decreasing in developed countries, including in Taiwan, Japan, and Korea. This multicountry study surveyed the OB/GYN residents affiliated with the Taiwan Association of Obstetrics and Gynecology (TAOG), the Japanese Society of Obstetrics and Gynecology (JSOG), and the Korean Society of Obstetrics and Gynecology (KSOG) to evaluate the factors affecting the choice of pursing OB/GYN.

Methods: A 17-item questionnaire surveying the factors influencing the choice of pursuing a major medical specialty was translated into Japanese, Korean, and Chinese and administered to postgraduate OB/GYN residents between July 1, 2020, and August 31, 2020.

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Objective: The recruitment of obstetrics and gynecology residents has been challenging in Taiwan since 2000. There are a lots factors influencing applying, including career interest and prospects, lifestyle, salary, litigation, stress level, time demands of specialty work and gender consideration. The purpose of this study was to evaluate the factors influencing the career choice of current OB/GYN residents and identify the important factors influencing recruitment.

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During pregnancy, a woman's enlarged uterus and the developing fetus lead to symptom distress; in turn, physical and psychological aspects of symptom distress are often associated with adverse prenatal and birth outcomes. This study aimed to identify the trends in the trajectory of these symptoms. This longitudinal study recruited 95 pregnant women, with a mean age of 32 years, from the prenatal wards of two teaching hospitals in northern Taiwan.

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Low levels of physical activity (PA) are of a health concern among high body mass index (BMI) women living a sedentary lifestyle and being overweight or obese during pregnancy is associated with increased risks of maternal and fetal health complications. Obstetricians often provide advice regarding recommended PA levels, yet this has not been easily achieved in this group to prevent adverse birth-related outcomes. The purpose of this study is to explore motivators/enablers and perceived barriers through in-depth qualitative inquiry, guided by a behavioral change model, for understanding of pregnant women's decisions to engage, or refrain from PA practice.

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