Publications by authors named "Jian-Bin Zeng"
Article Synopsis
- Eucommia cortex is a key herb in traditional Chinese medicine for treating osteoporosis, and pinoresinol diglucoside (PDG) is its main active component that shows promise in this area but lacks clarity on its metabolic behavior and action against osteoporosis.
- Researchers used advanced chromatography and mass spectrometry to analyze how PDG is metabolized in rats, identifying 51 metabolites and various metabolic processes such as glucuronidation and sulfation.
- The findings suggest that PDG may combat osteoporosis through its metabolites by targeting specific proteins involved in key signaling pathways, laying the groundwork for further studies on PDG's therapeutic potential.
Osthole (also known as Osthol) is the main anti-inflammatory coumarin found in Cnidium monnieri and severs as the exclusive quality-controlled component according the Chinese Pharmacopoeia. However, its underlying anti-inflammatory mechanism remains unknown. In this study, we demonstrated that Osthole treatment significantly inhibited the generation of TNF-α, but not IL-6 in the classical LPS-stimulated RAW264.
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