Diquat exposure causes brainstem demyelination by upregulating the mitochondrial calcium uniporter.

Diquat (DQ) is a widely used new herbicide that poses a great threat to the environment, ecological systems and human health. Although the central nervous system (CNS) is a sensitive target of DQ exposure, the major brain regions, pathological changes and underlying mechanisms of DQ damage to the CNS remain obscure. We demonstrated that the brainstem was the primary region where DQ damaged the CNS.

Predictive Application Value of Metagenomic Next-Generation Sequencing in the Resistance of Carbapenem-Resistant Enterobacteriaceae.

Although metagenomic next-generation sequencing (mNGS) technology has achieved notable outcomes in pathogen detection, there remains a gap in the research regarding its application in predicting the antibiotic resistance of pathogenic bacteria. This study aims to analyze the clinical application value of mNGS in predicting the resistance of carbapenem-resistant Enterobacteriaceae (CRE), as well as the relevant influencing factors, thereby providing valuable insights for clinical antimicrobial therapy. Nonduplicate isolates of bacteria collected from Liaocheng People's Hospital from April 2023 to June 2024 were selected, and CRE bacteria were screened.

Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population.

Coronary artery disease (CAD) is often accompanied by abnormal cardiac structure and function, leading to an increased prognostic risk. However, less is known about the associations of mixed metals with abnormal cardiac structure and function in CAD patients. Here, we aimed to investigate the associations of exposure to metal mixtures with cardiac structure and function and potential interactions in a CAD population.

Association of multiple blood metals and systemic atherosclerosis: A cross-sectional study in the CAD population.

Background: Coronary atherosclerotic disease (CAD) is often accompanied by peripheral atherosclerosis, resulting in a higher risk of ischemia and cardiovascular death. Exposure to metals is associated with atherosclerotic plaques at specific sites. However, less is known about the effects of mixed metals on systemic atherosclerotic burden in CAD patients.

Urinary neonicotinoids and metabolites are associated with obesity risk in Chinese school children.

Background: Neonicotinoids are the most widely used insecticides. Laboratory studies have suggested that neonicotinoids are one potential obesogen, but relevant data are limited in human.

Objective: To examine the association between exposure to neonicotinoids and childhood obesity.

Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish.

Cadmium (Cd) exposure is a risk factor for endothelial dysfunction and cardiovascular disease. Ferroptosis is a type of cell death that relies on lipid peroxidation. Whether ferroptosis acts in Cd-induced vascular endothelial damage and the underlying mechanisms remain unclear.