Optimal exercise therapy to improve cognitive function in middle-aged and elderly patients with stroke: A systematic review with pairwise and network meta-analyses.

Objective: This study investigated the effects of different exercise therapies on the improvement of cognitive function in middle-aged and elderly patients with stroke and analyzed the optimal form of exercise therapy.

Methods: A literature search was conducted in five databases: Web of Science, Embase, Cochrane Library, PubMed, and SPORTDiscus. The search was conducted from the creation of the databases until August 15, 2024.

Acute effects of short-term high-intensity interval exercise and moderate-intensity aerobic exercise on food-related inhibitory control in obese adults: a randomized controlled crossover trial using ERP measures.

Introduction: Food-specific inhibitory control plays a critical role in maintaining a healthy body weight. However, limited research has explored how different exercise modalities influence this form of control in adults with obesity, particularly regarding the underlying neural mechanisms. This study aimed to examine the acute effects of short-term high-intensity interval exercise (HIIE) and moderate-intensity aerobic exercise (MIAE) on food-related inhibitory function in obese adults, and to assess whether sex differences modulate the response to exercise interventions.

Optimal exercise therapy for improving executive function in middle-aged and older patients with mild cognitive impairment: A systematic review with pairwise and network meta-analyses.

Objective: In this study, we analyzed the improvement effects of different forms of exercise on executive function in middle-aged and older patients with mild cognitive impairment and summarized the best forms of exercise to improve working memory, cognitive flexibility, and inhibitory function.

Methods: Data were searched in SPORTDiscus, Cochrane library, PubMed, Embase and Web of Science databases. Manual search was also conducted by literature tracing method to obtain supplementary data.

[Rapid identification and analysis of hemoglobin isoelectric focusing electrophoresis images based on deep learning].

Gel electrophoresis is used to separate and analyze macromolecules （such as DNA， RNA， and proteins） and their fragments， and highly reproducible and efficient automatic band-detection methods have been developed to analyze gel images. Uneven background， low contrast， lane distortion， blurred band edges， and geometric deformation pose detection-accuracy challenges during automatic band detection. In order to address these issues， various correction algorithms have been proposed； however， these algorithms rely on researcher experience to adjust and optimize parameters based on image characteristics， which introduces human error while qualitatively and quantitatively processing bands.

Effects of exercise combined with cognitive dual-task training on cognitive function and sustained effects in stroke patients: a systematic review and meta-analysis.

Objectives: We investigated the effect of exercise combined with cognitive dual-task training on the improvement of cognitive function in stroke patients by conducting a systematic review and meta-analysis of current relevant studies.

Methods: Four electronic databases, PubMed, Web of Science, Cochrane Library, and Embase, were searched for randomized controlled trials (RCTs) on the effects of exercise combined with cognitive dual-task training on cognitive function in patients with stroke that were publicly available from the starting year of the databases to 10 July 2024.

Results: A total of 14 RCTs were included.

Optimal exercise intensity for improving executive function in patients with attention deficit hyperactivity disorder: systematic review and network meta-analysis.

This study aimed to compare and rank the effectiveness of optimal exercise intensity in improving executive function in patients with ADHD (Attention deficit hyperactivity disorder, ADHD) through a comprehensive comparison of direct and indirect evidence. A systematic search was performed in five electronic databases to explore the optimal exercise intensity for improving executive function in patients with ADHD by directly and indirectly comparing a variety of exercise intervention intensities. In addition, the isolated effects of exercise on improving executive function in patients with ADHD were explored through classical meta-analysis of paired direct comparisons.

Network meta-analysis of the effects of different cognitive trainings on the cognitive function of patients with mild cognitive impairment.

Objective: Examining the relationship between the responses of a number of different cognitive trainings on cognitive functioning in middle-aged and elderly patients with mild cognitive impairment.

Methods: Randomized controlled experimental studies published publicly from the time of inception to October 30, 2023 were searched through Web of Science, PubMed, Embase, and Cochrane library databases. Traditional and network meta-analyses were performed using Stata 17.

Reliability and Validity of the Star Excursion Balance Test for Evaluating Dynamic Balance of Upper Extremities.

Background: Upper extremity (UE) dynamic balance is a significant physical fitness ability, which includes high-level neuromuscular proprioception, joint mobility, force, and coordination. The evaluation methods of UE dynamic balance are insufficient and lack experimental support. The Star Excursion Balance Test (SEBT) is a reliable assessment of dynamic balance and injury risk of the lower extremity.

Single Exercise for Core Symptoms and Executive Functions in ADHD: A Systematic Review and Meta-Analysis.

Objectives: A systematic review and meta-analysis of studies of single exercise on core symptoms and executive function in adolescents with ADHD.

Methods: Four databases were searched for studies of the effects of single exercise on core symptoms and executive functioning in adolescents with ADHD.

Results: Thirteen studies were included, and a single session of exercise had small effect-size improvements in core symptoms and executive function in adolescents with ADHD: 10 to 13 year olds in the early adolescent-elementary school years and 18 to 24 year olds in the late adolescent-college years.

Research trends and frontiers in exercise for movement disorders: A bibliometric analysis of global research from 2010 to 2021.

Objective: To conduct a bibliometric analysis of trends and frontiers on exercise-based non-pharmacological treatments for movement disorders published between 2010 and 2021.

Methods: The Web of Science (WOS) Core Collection database was searched for articles published between 2010 and 2021. The CiteSpace software was used for in-depth analysis of the countries, institutions, journals, and collaboration networks among authors and their types of articles, developmental directions, references, and hot keywords of published articles.

Research Hotspots and Trends of Exercise on Parkinson's Disease: A Global Bibliometric Analysis From 2012 to 2021.

Background: Parkinson's disease is a chronic neurodegenerative disease, which can be alleviated in drug treatment, but with evident side effects. At the same time, increasing evidence shows that exercise can significantly improve the symptoms of patients with Parkinson's disease, with an effect that cannot be achieved by drug treatment. The related research on exercise on Parkinson's disease increases rapidly with the passage of time.

MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression.

Accumulating evidence has indicated that aberrantly expressed microRNAs (miRs) are extensively involved in cancer development and progression. MiR-639 has been reported to act as tumor promoter in various types of cancer. However, the biological function and underlying molecular mechanism of miR-639 in thyroid carcinoma (TC) have not been intensively investigated.

MiR-384 regulated IRS1 expression and suppressed cell proliferation of human hepatocellular carcinoma.

Acquired evidence indicated that microRNAs (miRNAs) played essential roles in cancer development, including hepatocellular carcinoma (HCC). Functions and mechanisms of miRNAs involved in HCC remain largely unknown. Here, we found that miR-384 was significantly downregulated in HCC cells and tissues by RT-PCR.

Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition.

Colorectal cancer (CRC) remains one of the most common cancers worldwide. Increasing evidence indicates that SPRY4 intronic transcript 1 (SPRY4-IT1) regulate cell growth, differentiation, apoptosis, and cancer progression. However, the expression and function of SPRY4-IT1 in the progression of CRC remains largely unknown.

Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer.

Cyclin-dependent kinase (CDK) family members have been considered as attractive therapeutic targets for cancer. In this study, we aim to investigate the anticancer effects of a selective CDK7 inhibitor, BS-181, in gastric cancer (GC) cell line. Human GC cells (BGC823) were cultured with or without BS-181 at different concentrations for 24-72 hours.

The association between serum ferritin with colorectal cancer.

There are conflicting reports on the correlation between serum levels of ferritin with colorectal cancer. The purpose of the present study is to clarify the association between serum ferritin with colorectal cancer using a meta-analysis approach. We searched articles indexed in Pubmed published as of July 2015 that met our predefined criteria.

Downregulation of CDK-8 inhibits colon cancer hepatic metastasis by regulating Wnt/β-catenin pathway.

Liver metastasis is a major cause of mortality from colon cancer. To investigate the role of cyclin-dependent kinase 8 (CDK8) in the progression of colon cancer hepatic metastasis. In this present study, human colon cancer HCT116 or HCT116-LUC-GFP cells were transfected with Lentiviral vector-mediated knockdown of CDK-8.

MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression.

MicroRNAs (miRNAs) have emerged as important regulators that potentially play critical roles in cancer cell biological processes. Previous studies have shown that miR-492 plays an important role in cell tumorigenesis in multiple kinds of human cancer cells. However, the underlying mechanisms of this microRNA in breast cancer remain largely unknown.

Triptolide induces apoptosis of gastric cancer cells via inhibiting the overexpression of MDM2.

Triptolide has been reported to exhibit antitumor effects in several cancers. This study investigates the mechanism by which triptolide induces apoptosis of gastric cancer cells. Gastric biopsies were collected for histological evaluation and detection of murine double minute 2 (MDM2) expression.

Immunoassay using surface-enhanced Raman scattering based on aggregation of reporter-labeled immunogold nanoparticles.

A one-step homogenous sensitive immunoassay using surface-enhanced Raman scattering (SERS) has been developed. This strategy is based on the aggregation of Raman reporter-labeled immunogold nanoparticles induced by the immunoreaction with corresponding antigens. The aggregation of gold nanoparticles results in a SERS signal increase of the Raman reporter.

Electrochemical detection of thrombin by sandwich approach using antibody and aptamer.

The goal of this work was to introduce a modified electrochemical sandwich model for target protein detection, exploiting antibody as the capturing probe, aptamer as the detection probe and methylene blue as the electrochemical active marker intercalating in the probing aptamer without previous labeling. With appropriate design of the sequence of the aptamer, the aptamer was successfully utilized instead of antibody for obtaining the electrochemical detection. A special immobilization interface consisting of nanogold-chitosan composite film was used to improve the conductivity and performance characteristics of the electrode.

Detection of adenosine using surface-enhanced Raman scattering based on structure-switching signaling aptamer.

In the present study, we report a novel sensitive method for the detection of adenosine using surface-enhanced Raman scattering (SERS) sensing platform based on a structure-switching aptamer. First, Ag-clad Au colloids film on a polished gold disc is prepared as enhanced substrate and modified with thiolated capture DNA. The formation of an aptamer/DNA duplex of expanded anti-adenosine aptamer and tetramethylrhodamine-labeled DNA (denoted TMR-DNA) is then developed, in which TMR-DNA could also hybridize completely with capture DNA.

Ag/SiO2 core-shell nanoparticle-based surface-enhanced Raman probes for immunoassay of cancer marker using silica-coated magnetic nanoparticles as separation tools.

A simple, sensitive and highly specific immunoassay has been developed based on surface-enhanced Raman scattering for human alpha-fetoprotein (AFP), a tumor marker for the diagnosis of hepatocellular carcinoma. This strategy combines the Ag/SiO2 core-shell nanoparticles embedded with rhodamine B isothiocyanate dye molecules as Raman tags and the amino group modified silica-coated magnetic nanoparticle as immobilization matrix and separation tool. In the proposed system, a sandwich-type immunoassay was performed between polyclonal antibody functionalized Ag/SiO2 nanoparticle-based Raman tags and monoclonal antibody modified silica-coated magnetic nanoparticles.

Effect of complex amino acid imbalance on growth of tumor in tumor-bearing rats.

Aim: To investigate the effect of complex amino acid imbalance on the growth of tumor in tumor-bearing (TB) rats.

Methods: Sprague-Dawley (SD) rats underwent jejunostomy for nutritional support. A suspension of Walker-256 carcinosarcoma cells was subcutaneously inoculated.

Prevention and therapy of fungal infection in severe acute pancreatitis: A prospective clinical study.

Aim: To investigate the prevention and therapy of fungal infection in patients with severe acute pancreatitis (SAP).

Methods: Seventy patients with SAP admitted from Jan. 1998 to Dec.